Melanin-concentrating hormone receptor 2 explained

Melanin-concentrating hormone receptor 2 (MCH₂) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.^{[1] [2] [3]}

MCH₂ is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.^[4]

See also

• Melanin-concentrating hormone receptor

External links

• Web site: Melanin-Concentrating Hormone Receptors: MCH₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-05 . 2016-03-03 . https://web.archive.org/web/20160303190301/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2999 . dead .

Further reading

• Sailer AW, Sano H, Zeng Z, etal . Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 13 . 7564–9 . 2001 . 11404457 . 10.1073/pnas.121170598 . 34708 . 2001PNAS...98.7564S . free .
• An S, Cutler G, Zhao JJ, etal . Identification and characterization of a melanin-concentrating hormone receptor. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 13 . 7576–81 . 2001 . 11416225 . 10.1073/pnas.131200698 . 34710 . 2001PNAS...98.7576A . free .
• Wang S, Behan J, O'Neill K, etal . Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. . J. Biol. Chem. . 276 . 37 . 34664–70 . 2001 . 11459838 . 10.1074/jbc.M102601200 . free .
• Bednarek MA, Feighner SD, Hreniuk DL, etal . Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. . Biochemistry . 40 . 31 . 9379–86 . 2001 . 11478907 . 10.1021/bi010867p .
• Bednarek MA, Tan C, Hreniuk DL, etal . Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. . J. Biol. Chem. . 277 . 16 . 13821–6 . 2002 . 11839762 . 10.1074/jbc.M200563200 . free .
• Audinot V, Lahaye C, Suply T, etal . SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. . Biochem. Biophys. Res. Commun. . 295 . 4 . 841–8 . 2002 . 12127971 . 10.1016/S0006-291X(02)00763-5 .
• Logan DW, Bryson-Richardson RJ, Pagán KE, etal . The structure and evolution of the melanocortin and MCH receptors in fish and mammals. . Genomics . 81 . 2 . 184–91 . 2003 . 12620396 . 10.1016/S0888-7543(02)00037-X .
• Vitale RM, Pedone C, De Benedetti PG, Fanelli F . Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. . Proteins . 56 . 3 . 430–48 . 2004 . 15229878 . 10.1002/prot.20125 . 8915054 .
• Hawes BE, Green B, O'Neill K, etal . Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. . Obes. Res. . 12 . 8 . 1327–34 . 2004 . 15340116 . 10.1038/oby.2004.167 .

Notes and References

1. Web site: Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2.
2. Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M . Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor . Biochem. Biophys. Res. Commun. . 283 . 5 . 1013–8 . May 2001 . 11355873 . 10.1006/bbrc.2001.4893 .
3. Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI . Molecular cloning and functional characterization of MCH2, a novel human MCH receptor . J. Biol. Chem. . 276 . 23 . 20125–9 . June 2001 . 11274220 . 10.1074/jbc.M102068200 . free .
4. Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ . Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction . Horm. Metab. Res. . 42 . 7 . 521–7 . June 2010 . 20340065 . 10.1055/s-0030-1249019 . 25733080 .