MCC (gene) explained

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.^[1]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.^[2]

Further reading

• Lindgren V, Bryke CR, Ozcelik T, etal . Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis . Am. J. Hum. Genet. . 50 . 5 . 988–97 . 1992 . 1315124 . 1682619 .
• Nishisho I, Nakamura Y, Miyoshi Y, etal . Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients . Science . 253 . 5020 . 665–9 . 1991 . 1651563 . 10.1126/science.1651563 . 1991Sci...253..665N .
• Hoshino Y, Horikawa I, Oshimura M, Yuasa Y . Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity . Biochem. Biophys. Res. Commun. . 174 . 1 . 298–304 . 1991 . 1846539 . 10.1016/0006-291X(91)90520-H .
• Curtis LJ, Bubb VJ, Gledhill S, etal . Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer . Hum. Mol. Genet. . 3 . 3 . 443–6 . 1994 . 8012355 . 10.1093/hmg/3.3.443 .
• Matsumine A, Senda T, Baeg GH, etal . MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase . J. Biol. Chem. . 271 . 17 . 10341–6 . 1996 . 8626604 . 10.1074/jbc.271.17.10341 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A . Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers . Science . 251 . 4999 . 1366–70 . Apr 1991 . 1848370 . 10.1126/science.1848370 . 1991Sci...251.1366K . etal. 40048385 .
2. Web site: Entrez Gene: MCC mutated in colorectal cancers.