MBOAT7 explained

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.^[1] It is homologous to other membrane-bound O-acyltransferases.^{[2] [3]}

Function

This gene encodes a member of the membrane-bound O-acyltransferase family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.^{[1] [2]}

Further reading

• Wende H, Volz A, Ziegler A . Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster . Immunogenetics . 51 . 8–9 . 703–13 . July 2000 . 10941842 . 10.1007/s002510000187. 20719684 .
• Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H . Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol . Mol. Biol. Cell . 19 . 3 . 1174–84 . March 2008 . 18094042 . 2262980 . 10.1091/mbc.E07-09-0893 .
• Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T . Recent progress on acyl CoA: lysophospholipid acyltransferase research . J. Lipid Res. . 50 Suppl . S46–51 . April 2009 . Suppl . 18931347 . 2674719 . 10.1194/jlr.R800035-JLR200 . free .
• Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR . Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils . J. Biol. Chem. . 283 . 44 . 30235–45 . October 2008 . 18772128 . 2573059 . 10.1074/jbc.M806194200 . free .
• Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB . Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma . Anticancer Res. . 16 . 3A . 1085–90 . 1996 . 8702217 .

Notes and References

1. Web site: Entrez Gene: Membrane bound O-acyltransferase domain containing 7 .
2. Acyl-CoA:Lysophospholipid Acyltransferases. Shindou H, Shimizu T. Journal of Biological Chemistry. 2009. 284. 1. 1–5. 10.1074/jbc.R800046200. free. 18718904.
3. The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification. Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV. Nature Communications. 14. Art. No. 3533. 2023. 1 . 3533 . 10.1038/s41467-023-38932-5. free. 37316513. 10267149. 2023NatCo..14.3533W .