MB-3 (drug) explained

MB-3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferase enzyme GCN5, which usually functions as a negative modulator of PGC-1α, and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation.[1] [2] [3]

See also

Notes and References

  1. Biel M, Kretsovali A, Karatzali E, Papamatheakis J, Giannis A . Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5 . Angewandte Chemie . 43 . 30 . 3974–6 . July 2004 . 15274229 . 10.1002/anie.200453879 .
  2. Mai A, Rotili D, Tarantino D, Ornaghi P, Tosi F, Vicidomini C, Sbardella G, Nebbioso A, Miceli M, Altucci L, Filetici P . 6 . Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties . Journal of Medicinal Chemistry . 49 . 23 . 6897–907 . November 2006 . 17154519 . 10.1021/jm060601m .
  3. Xu H, Zhou Q, Yi Q, Tan B, Tian J, Chen X, Wang Y, Yu X, Zhu J . 6 . Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes . Scientific Reports . 10 . 1 . 1817 . February 2020 . 32019948 . 10.1038/s41598-020-58387-8 . 7000709 . 2020NatSR..10.1817X . free .

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