Map44 Explained

Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 ^[1]

See also

• mannan-binding lectin
• lectin pathway

Notes and References

1. Degn SE, Hansen AG, Steffensen R, Jacobsen C, Jensenius JC, Thiel S . MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation . Journal of Immunology . 183 . 11 . 7371–8 . December 2009 . 19917686 . 10.4049/jimmunol.0902388 . free .