MAZ (gene) explained

Myc-associated zinc finger protein is a protein that in humans is encoded by the MAZ gene.^{[1] [2] [3]}

Interactions

MAZ (gene) has been shown to interact with BPTF^[4] and Deleted in Colorectal Cancer.^[5]

Further reading

• Parks CL, Shenk T . The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. . J. Biol. Chem. . 271 . 8 . 4417–4430 . 1996 . 8626793 . 10.1074/jbc.271.8.4417 . free .
• Tsutsui H, Sakatsume O, Itakura K, Yokoyama KK . Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells. . Biochem. Biophys. Res. Commun. . 226 . 3 . 801–809 . 1996 . 8831693 . 10.1006/bbrc.1996.1432 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Song J, Murakami H, Tsutsui H, Tang X, Matsumura M, Itakura K, Kanazawa I, Sun K, Yokoyama KK . Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ). . J. Biol. Chem. . 273 . 32 . 20603–20614 . 1998 . 9685418 . 10.1074/jbc.273.32.20603 . free .
• Song J, Murakami H, Yang ZQ, Koga C, Adati N, Murata T, Geltinger C, Saito-Ohara F, Ikeuchi T, Matsumura M, Itakura K, Kanazawa I, Sun K, Yokoyama KK . Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2. . Genomics . 52 . 3 . 374–377 . 1998 . 9790757 . 10.1006/geno.1998.5452 .
• Tsutsui H, Geltinger C, Murata T, Itakura K, Wada T, Handa H, Yokoyama KK . The DNA-binding and transcriptional activities of MAZ, a myc-associated zinc finger protein, are regulated by casein kinase II. . Biochem. Biophys. Res. Commun. . 262 . 1 . 198–205 . 1999 . 10448092 . 10.1006/bbrc.1999.1130 .
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. . Genomics . 60 . 3 . 295–308 . 1999 . 10493829 . 10.1006/geno.1999.5927 .
• Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R . Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. . Biochemistry . 39 . 12 . 3206–3215 . 2000 . 10727212 . 10.1021/bi992211q . 3667205 .
• Ugai H, Li HO, Komatsu M, Tsutsui H, Song J, Shiga T, Fearon E, Murata T, Yokoyama KK . Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. . Biochem. Biophys. Res. Commun. . 286 . 5 . 1087–1097 . 2001 . 11527412 . 10.1006/bbrc.2001.5469 .
• Ray BK, Murphy R, Ray P, Ray A . SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription. . J. Biol. Chem. . 277 . 48 . 46822–46830 . 2003 . 12270922 . 10.1074/jbc.M206299200 . free .
• Bataller L, Wade DF, Graus F, Rosenfeld MR, Dalmau J . The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar dysfunction. . Ann. Neurol. . 53 . 1 . 123–127 . 2004 . 12509857 . 10.1002/ana.10434 . 25532793 .
• Ray A, Kuroki K, Cook JL, Bal BS, Kenter K, Aust G, Ray BK . Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritis. . Arthritis Rheum. . 48 . 1 . 134–145 . 2003 . 12528113 . 10.1002/art.10706 .
• Leroy C, Manen D, Rizzoli R, Lombès M, Silve C . Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity. . J. Mol. Endocrinol. . 32 . 1 . 99–113 . 2005 . 14765995 . 10.1677/jme.0.0320099 . free .
• Ray A, Shakya A, Kumar D, Ray BK . Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression. . J. Immunol. . 172 . 8 . 5006–5015 . 2004 . 15067082 . 10.4049/jimmunol.172.8.5006 . free .
• Ray BK, Shakya A, Turk JR, Apte SS, Ray A . Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process. . Circ. Res. . 95 . 11 . 1082–1090 . 2005 . 15528467 . 10.1161/01.RES.0000150046.48115.80 . free .
• Gromak N, West S, Proudfoot NJ . Pause sites promote transcriptional termination of mammalian RNA polymerase II. . Mol. Cell. Biol. . 26 . 10 . 3986–3996 . 2006 . 16648491 . 1488997 . 10.1128/MCB.26.10.3986-3996.2006 .
• Ray A, Shakya A, Kumar D, Benson MD, Ray BK . Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis. . J. Immunol. . 177 . 4 . 2601–2609 . 2006 . 16888022 . 10.4049/jimmunol.177.4.2601 . free .

Notes and References

1. Pyrc JJ, Moberg KH, Hall DJ . Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter . Biochemistry . 31 . 16 . 4102–4110 . May 1992 . 1567856 . 10.1021/bi00131a029 .
2. Bossone SA, Asselin C, Patel AJ, Marcu KB . MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination . Proc Natl Acad Sci U S A . 89 . 16 . 7452–7456 . September 1992 . 1502157 . 49728 . 10.1073/pnas.89.16.7452 . 1992PNAS...89.7452B . free .
3. Web site: Entrez Gene: MAZ MYC-associated zinc finger protein (purine-binding transcription factor).
4. Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R . Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity . Biochemistry . 39 . 12 . 3206–3215 . March 2000 . 10727212 . 10.1021/bi992211q . 3667205 .
5. Ugai H, Li HO, Komatsu M, Tsutsui H, Song J, Shiga T, Fearon E, Murata T, Yokoyama KK . Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells . Biochem. Biophys. Res. Commun. . 286 . 5 . 1087–1097 . September 2001 . 11527412 . 10.1006/bbrc.2001.5469 .