MATR3 explained

Matrin-3 is a protein that in humans is encoded by the MATR3 gene.^{[1] [2]}

Function

The protein encoded by this gene is localized in the nuclear matrix. It may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. Two transcript variants encoding the same protein have been identified for this gene.

Pathology

Mutations in the Matrin 3 gene are associated with familial amyotrophic lateral sclerosis.^[3]

Further reading

• Stuurman N . The nuclear matrix from cells of different origin. Evidence for a common set of matrix proteins . J. Biol. Chem. . 265 . 10 . 5460–5 . 1990 . 2180926 . Meijne AM . van der Pol AJ . 3 . De Jong . L . Van Driel . R . Van Renswoude . J . 10.1016/S0021-9258(19)39383-4 . free .
• Andersson B . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . Wentland MA . Ricafrente JY . 3 . Liu . W . Gibbs . RA .
• Yu W . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . Andersson B . Worley KC . 3 . Muzny . DM . Ding . Y . Liu . W . Ricafrente . JY . Wentland . MA . Lennon . G .
• Okumara K . Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3 . Biosci. Biotechnol. Biochem. . 62 . 8 . 1640–2 . 1998 . 9757574 . 10.1271/bbb.62.1640 . Nogami M . Matsushima Y . 3 . Matsumura . Kiyoshi . Nakamura . Kazuyasu . Taguchi . Hiroshi . Kitagawa . Yasuo . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 5 . 277–86 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . Ishikawa K . Suyama M . 3 . Kikuno . R . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . Ohara . O . free .
• Hu RM . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . Han ZG . Song HD . 3 . Peng . YD . Huang . QH . Ren . SX . Gu . YJ . Huang . CH . Li . YB . 2000PNAS...97.9543H . free .
• Zhang Z, Carmichael GG . The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs . Cell . 106 . 4 . 465–75 . 2001 . 11525732 . 10.1016/S0092-8674(01)00466-4 . 18799711 . free .
• Bernert G, Fountoulakis M, Lubec G . Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain . Proteomics . 2 . 12 . 1752–7 . 2003 . 12469345 . 10.1002/1615-9861(200212)2:12<1752::AID-PROT1752>3.0.CO;2-Y . 32160196 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Zhang C . Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing . J. Biol. Chem. . 278 . 37 . 35325–36 . 2003 . 12840015 . 10.1074/jbc.M305191200 . Dowd DR . Staal A . 3 . Gu . C . Lian . JB . Van Wijnen . AJ . Stein . GS . MacDonald . PN . free .
• Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochem. Biophys. Res. Commun. . 308 . 4 . 793–801 . 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 . 10.1.1.539.8359 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Lim J . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . Hao T . Shaw C . 3 . Patel . Akash J. . Szabó . Gábor . Rual . Jean-François . Fisk . C. Joseph . Li . Ning . Smolyar . Alex . 13709685 . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free .
• Ewing RM . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
• Valencia CA, Ju W, Liu R . Matrin 3 is a Ca2+/calmodulin-binding protein cleaved by caspases . Biochem. Biophys. Res. Commun. . 361 . 2 . 281–6 . 2007 . 17658460 . 10.1016/j.bbrc.2007.06.156 .

Notes and References

1. Belgrader P, Dey R, Berezney R . Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain . J Biol Chem . 266 . 15 . 9893–9 . Jun 1991 . 10.1016/S0021-9258(18)92902-9 . 2033075 . free .
2. Web site: Entrez Gene: MATR3 matrin 3.
3. Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ . Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis . Nat. Neurosci. . 17. 5. 664–6. 2014 . 24686783 . 10.1038/nn.3688 . 4000579.