MAST2 explained

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.^[1] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.^[2]

Interactions

MAST2 has been shown to interact with PCLKC.^[3]

Further reading

• Walden PD, Cowan NJ . A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette . Mol. Cell. Biol. . 13 . 12 . 7625–35 . 1993 . 8246979 . 364834 . 10.1128/mcb.13.12.7625.
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Walden PD, Millette CF . Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis . Biol. Reprod. . 55 . 5 . 1039–44 . 1996 . 8902215 . 10.1095/biolreprod55.5.1039 . free .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 5 . 277–86 . 1998 . 9872452 . 10.1093/dnares/5.5.277 . free .
• Lumeng C, Phelps S, Crawford GE, Walden PD, Barald K, Chamberlain JS . Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases . Nat. Neurosci. . 2 . 7 . 611–7 . 1999 . 10404183 . 10.1038/10165 . 20910888 .
• Adey NB, Huang L, Ormonde PA, Baumgard ML, Pero R, Byreddy DV, Tavtigian SV, Bartel PL . Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding . Cancer Res. . 60 . 1 . 35–7 . 2000 . 10646847 .
• Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H . Interaction of the type IIa Na/Pi cotransporter with PDZ proteins . J. Biol. Chem. . 276 . 12 . 9206–13 . 2001 . 11099500 . 10.1074/jbc.M008745200 . free .
• Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H . Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation . Carcinogenesis . 23 . 7 . 1139–48 . 2002 . 12117771 . 10.1093/carcin/23.7.1139 . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs . Genome Res. . 12 . 11 . 1773–84 . 2002 . 12421765 . 187542 . 10.1101/gr.406902 .
• Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I . Proteomic identification of brain proteins that interact with dynein light chain LC8 . Proteomics . 4 . 2 . 339–46 . 2004 . 14760703 . 10.1002/pmic.200300528 . 8868600 .
• Zhou H, Xiong H, Li H, Plevy SE, Walden PD, Sassaroli M, Prestwich GD, Unkeless JC . Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation . J. Immunol. . 172 . 4 . 2559–68 . 2004 . 14764729 . 10.4049/jimmunol.172.4.2559 . 85692192 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Xiong H, Li H, Chen Y, Zhao J, Unkeless JC . Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability . J. Biol. Chem. . 279 . 42 . 43675–83 . 2004 . 15308666 . 10.1074/jbc.M404328200 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Web site: Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2.
2. Xiong H, Li H, Chen Y, Zhao J, Unkeless JC . Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability . J. Biol. Chem. . 279 . 42 . 43675–83 . 2004 . 15308666 . 10.1074/jbc.M404328200 . free .
3. Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H . Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation . Carcinogenesis . 23 . 7 . 1139–48 . July 2002 . 12117771 . 10.1093/carcin/23.7.1139 . free .