MASP2 (protein) explained

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.^{[1] [2] [3]}

Function

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.^[1]

MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.

See also

• MASP1 (protein)
• Mannan-binding lectin
• Mannan-binding lectin pathway (lectin pathway)

References

Further reading

• Petersen SV, Thiel S, Jensenius JC . The mannan-binding lectin pathway of complement activation: biology and disease association . Mol. Immunol. . 38 . 2–3 . 133–49 . 2001 . 11532276 . 10.1016/S0161-5890(01)00038-4 .
• Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ . Common variation in genes related to innate immunity and risk of adult glioma. . Cancer Epidemiol. Biomarkers Prev. . 18 . 5 . 1651–8 . 2009 . 19423540 . 2771723 . 10.1158/1055-9965.EPI-08-1041 .
• McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF . Integrative predictive model of coronary artery calcification in atherosclerosis. . Circulation . 120 . 24 . 2448–54 . 2009 . 19948975 . 2810344 . 10.1161/CIRCULATIONAHA.109.865501 .
• Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K . Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot. . Immunology . 129 . 4 . 482–95 . 2010 . 20002787 . 2842495 . 10.1111/j.1365-2567.2009.03200.x .
• Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL . Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. . Br. J. Haematol. . 145 . 5 . 614–23 . 2009 . 19344414 . 2820509 . 10.1111/j.1365-2141.2009.07675.x .
• Wang Y, Yan J, Shi Y, Li P, Liu C, Ma Q, Yang R, Wang X, Zhu L, Yang X, Cao C . Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection. . BMC Infect. Dis. . 9 . 51 . 2009 . 19405982 . 2683852 . 10.1186/1471-2334-9-51 . free .
• Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D . Polymorphisms in innate immunity genes and risk of childhood leukemia. . Hum. Immunol. . 71 . 7 . 727–30 . 2010 . 20438785 . 2967770 . 10.1016/j.humimm.2010.04.004 .
• Kocsis A, Kékesi KA, Szász R, Végh BM, Balczer J, Dobó J, Závodszky P, Gál P, Pál G . Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation. . J. Immunol. . 185 . 7 . 4169–78 . 2010 . 20817870 . 10.4049/jimmunol.1001819 . free . 10831/91219 . free .
• Segat L, Milanese M, Pirulli D, Trevisiol C, Lupo F, Salizzoni M, Amoroso A, Crovella S . Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. . J. Gastroenterol. Hepatol. . 24 . 12 . 1840–6 . 2009 . 19817957 . 10.1111/j.1440-1746.2009.06009.x . 205464848 .
• Smithson A, Perello R, Aibar J, Espinosa G, Tassies D, Freire C, Castro P, Suarez B, Lozano F, Nicolas JM . Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome. . Clin. Vaccine Immunol. . 17 . 3 . 447–53 . 2010 . 20042521 . 2837953 . 10.1128/CVI.00375-09 .
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. . Am. J. Hum. Genet. . 85 . 5 . 628–42 . 2009 . 19913121 . 2775832 . 10.1016/j.ajhg.2009.10.014 .
• Ytting H, Christensen IJ, Steffensen R, Alsner J, Thiel S, Jensenius JC, Hansen U, Nielsen HJ . Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer. . Scand. J. Immunol. . 73 . 2 . 122–7 . 2011 . 21198752 . 10.1111/j.1365-3083.2010.02480.x . free .
• Vallès X, Roca A, Lozano F, Morais L, Suárez B, Casals F, Mandomando I, Sigaúque B, Nhalungo D, Esquinas C, Quintó L, Alonso PL, Torres A . Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency. . Eur. Respir. J. . 36 . 4 . 856–63 . 2010 . 20150204 . 10.1183/09031936.00171409 . free .
• de Rooij BJ, van Hoek B, ten Hove WR, Roos A, Bouwman LH, Schaapherder AF, Porte RJ, Daha MR, van der Reijden JJ, Coenraad MJ, Ringers J, Baranski AG, Hepkema BG, Hommes DW, Verspaget HW . Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. . Hepatology . 52 . 3 . 1100–10 . 2010 . 20593422 . 10.1002/hep.23782 . 205875239 .
• Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD . Risk of meningioma and common variation in genes related to innate immunity. . Cancer Epidemiol. Biomarkers Prev. . 19 . 5 . 1356–61 . 2010 . 20406964 . 3169167 . 10.1158/1055-9965.EPI-09-1151 .
• Liu JL, Cao C, Ma QJ . [Study on interaction between SARS-CoV N and MAP19]. . Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi . 25 . 9 . 777–9 . 2009 . 19737459 .
• St Swierzko A, Cedzynski M, Domzalska-Popadiuk I, MacDonald SL, Borkowska-Klos M, Atkinson AP, Szala A, Jopek A, Jensenius JC, Kawakami M, Szczapa J, Matsushita M, Szemraj J, Turner ML, Kilpatrick DC . Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations . Mol. Immunol. . 46 . 8–9 . 1696–701 . 2009 . 19307021 . 10.1016/j.molimm.2009.02.022 .
• Vallès X, Sarrias MR, Casals F, Farnós M, Piñer R, Suárez B, Morais L, Mandomando I, Sigaúque B, Roca A, Alonso PL, Torres A, Thielens NM, Lozano F . Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children. . Tissue Antigens . 74 . 4 . 298–307 . 2009 . 19775369 . 10.1111/j.1399-0039.2009.01328.x .
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. . Diabetes Care . 33 . 10 . 2250–3 . 2010 . 20628086 . 2945168 . 10.2337/dc10-0452 .

Notes and References

1. Web site: Entrez Gene: mannan-binding lectin serine peptidase 2.
2. Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC . A second serine protease associated with mannan-binding lectin that activates complement . Nature . 386 . 6624 . 506–10 . April 1997 . 9087411 . 10.1038/386506a0 . 1997Natur.386..506T . 4261967 .
3. Vorup-Jensen T, Jensenius JC, Thiel S . MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway . Immunobiology . 199 . 2 . 348–57 . August 1998 . 9777418 . 10.1016/S0171-2985(98)80039-9 .