MAS1 explained

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene.^[1] The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).

Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).

See also

• MAS1 oncogene

Further reading

• Hanley MR . Molecular and cell biology of angiotensin receptors . Journal of Cardiovascular Pharmacology . 18 . S7-13 . 1992 . Suppl 2 . 1725048 . 10.1097/00005344-199106182-00003. free .
• Book: Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M . The mas Oncogene as a Neural Peptide Receptor: Expression, Regulation and Mechanism of Action . Ciba Foundation Symposium 150 - Proto-Oncogenes in Cell Development . Novartis Foundation Symposia . 150 . 23–38; discussion 38–46 . 1990 . 2197067 . 10.1002/9780470513927.ch3. 978-0-470-51392-7 .
• Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH . Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements . Oncogene Research . 1 . 2 . 169–78 . Jul 1987 . 3329713 .
• Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR . The mas oncogene encodes an angiotensin receptor . Nature . 335 . 6189 . 437–40 . Sep 1988 . 3419518 . 10.1038/335437a0 . 1988Natur.335..437J . 4360847 .
• Young D, Waitches G, Birchmeier C, Fasano O, Wigler M . Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains . Cell . 45 . 5 . 711–9 . Jun 1986 . 3708691 . 10.1016/0092-8674(86)90785-3 . 29886272 .
• Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM . The MAS proto-oncogene is not imprinted in humans . Genomics . 35 . 2 . 380–2 . Jul 1996 . 8661154 . 10.1006/geno.1996.0372 .
• Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR . Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene . Experimental Neurology . 163 . 1 . 207–19 . May 2000 . 10785460 . 10.1006/exnr.2000.7370 . 24445328 .
• Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T . Cell type-specific expression of the Mas proto-oncogene in testis . The Journal of Histochemistry and Cytochemistry . 50 . 5 . 691–6 . May 2002 . 11967280 . 10.1177/002215540205000510 . 44690751 .
• Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T . Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas . Proceedings of the National Academy of Sciences of the United States of America . 100 . 14 . 8258–63 . Jul 2003 . 12829792 . 166216 . 10.1073/pnas.1432869100 . 2003PNAS..100.8258S . free .
• Canals M, Jenkins L, Kellett E, Milligan G . Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS . The Journal of Biological Chemistry . 281 . 24 . 16757–67 . Jun 2006 . 16611642 . 10.1074/jbc.M601121200 . free .

Notes and References

1. Web site: Entrez Gene: MAS1 MAS1 oncogene.