MARS (gene) explained

Methionyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the MARS gene.^[1]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class I family of tRNA synthetases.^[2]

Further reading

• Norcum MT . Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents. . J. Biol. Chem. . 266 . 23 . 15398–405 . 1991 . 10.1016/S0021-9258(18)98629-1 . 1651330 . free .
• Ogata K, Kurahashi A, Kenmochi N, Terao K . Role of 5SrRNA as a positive effector of some aminoacyl-tRNA synthetases in macromolecular complexes, with specific reference to methionyl-tRNA synthetase. . J. Biochem. . 110 . 6 . 1037–44 . 1992 . 1665486 . 10.1093/oxfordjournals.jbchem.a123674.
• Cirullo RE, Wasmuth JJ . Assignment of the human MARS gene, encoding methioninyl-tRNA synthetase, to chromosome 12 using human X Chinese hamster cell hybrids. . Somat. Cell Mol. Genet. . 10 . 3 . 225–34 . 1984 . 6585969 . 10.1007/BF01535245 . 44887504 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Lage H, Dietel M . Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase . Gene . 178 . 1–2 . 187–9 . 1996 . 8921912 . 10.1016/0378-1119(96)00313-7 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Quevillon S, Robinson JC, Berthonneau E, etal . Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein . J. Mol. Biol. . 285 . 1 . 183–95 . 1999 . 9878398 . 10.1006/jmbi.1998.2316 .
• Ko YG, Kang YS, Kim EK, etal . Nucleolar Localization of Human Methionyl–Trna Synthetase and Its Role in Ribosomal RNA Synthesis . J. Cell Biol. . 149 . 3 . 567–74 . 2000 . 10791971 . 10.1083/jcb.149.3.567 . 2174846 .
• Kang J, Kim T, Ko YG, etal . Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases . J. Biol. Chem. . 275 . 41 . 31682–8 . 2000 . 10913161 . 10.1074/jbc.M909965199 . free .
• Kaminska M, Shalak V, Mirande M . The appended C-domain of human methionyl-tRNA synthetase has a tRNA-sequestering function . Biochemistry . 40 . 47 . 14309–16 . 2002 . 11714285 . 10.1021/bi015670b .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ahn HC, Kim S, Lee BJ . Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43 . FEBS Lett. . 542 . 1–3 . 119–24 . 2003 . 12729910 . 10.1016/S0014-5793(03)00362-4 . 39222196 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Ubeda M, Schmitt-Ney M, Ferrer J, Habener JF . CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability . Biochem Biophys Res Commun . 262 . 1 . 31–8 . Sep 1999 . 10448063 . 10.1006/bbrc.1999.1140 .
2. Web site: Entrez Gene: MARS methionyl-tRNA synthetase.