MARK3 explained

MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene.^{[1] [2]}

Interactions

MARK3 has been shown to interact with Stratifin.^{[3] [4]}

It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes.^[5]

Further reading

• Tassan JP, Le Goff X . An overview of the KIN1/PAR-1/MARK kinase family. . Biol. Cell . 96 . 3 . 193–9 . 2004 . 15182702 . 10.1016/j.biolcel.2003.10.009 . free .
• Meller N, Liu YC, Collins TL, Bonnefoy-Bérard N, Baier G, Isakov N, Altman A . Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. . Mol. Cell. Biol. . 16 . 10 . 5782–91 . 1996 . 8816492 . 231579 . 10.1128/MCB.16.10.5782.
• Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H . C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. . Cell Growth Differ. . 9 . 3 . 197–208 . 1998 . 9543386 .
• Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT . PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. . Nat. Cell Biol. . 3 . 7 . 628–36 . 2001 . 11433294 . 10.1038/35083016 . 1128604 .
• Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D . Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. . Oncogene . 22 . 30 . 4752–6 . 2003 . 12879020 . 10.1038/sj.onc.1206669 . 9945293 .
• Müller J, Ritt DA, Copeland TD, Morrison DK . Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. . EMBO J. . 22 . 17 . 4431–42 . 2003 . 12941695 . 202368 . 10.1093/emboj/cdg426 .
• Trinczek B, Brajenovic M, Ebneth A, Drewes G . MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. . J. Biol. Chem. . 279 . 7 . 5915–23 . 2004 . 14594945 . 10.1074/jbc.M304528200 . free .
• Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I . Proteomic identification of brain proteins that interact with dynein light chain LC8. . Proteomics . 4 . 2 . 339–46 . 2004 . 14760703 . 10.1002/pmic.200300528 . 8868600 .
• Bachmann M, Hennemann H, Xing PX, Hoffmann I, Möröy T . The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. . J. Biol. Chem. . 279 . 46 . 48319–28 . 2005 . 15319445 . 10.1074/jbc.M404440200 . free .
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. . Mol. Cell. Proteomics . 4 . 6 . 785–95 . 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein–protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein–protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Göransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR . Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. . J. Cell Sci. . 119 . Pt 19 . 4059–70 . 2007 . 16968750 . 10.1242/jcs.03097 . 582486 .
• Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R . New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. . Mol. Cell. Biol. . 26 . 19 . 7086–102 . 2006 . 16980613 . 1592903 . 10.1128/MCB.00231-06 .
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H . Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. . Mol. Cell. Proteomics . 6 . 3 . 537–47 . 2007 . 17192257 . 10.1074/mcp.T600062-MCP200 . free . 10033/19756 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein–protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Ono T, Kawabe T, Sonta S, Okamoto T . Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization . Cytogenet Cell Genet . 79 . 1–2 . 101–2 . April 1998 . 9533022 . 10.1159/000134692 .
2. Web site: Entrez Gene: MARK3 MAP/microtubule affinity-regulating kinase 3.
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein–protein interaction network . . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
4. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H . Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer . Mol. Cell. Proteomics . 4 . 6 . 785–95 . June 2005 . 15778465 . 10.1074/mcp.M500021-MCP200 . free .
5. Web site: Découverte d'un gène provoquant une cécité - Communiqués de presse - UNIGE. 23 July 2018.