MAPRE3 explained

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.^{[1] [2]}

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.

Further reading

• Juwana JP, Henderikx P, Mischo A, etal . EB/RP gene family encodes tubulin binding proteins . Int. J. Cancer . 81 . 2 . 275–84 . 1999 . 10188731 . 10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z . 33232892 . free .
• Nakagawa H, Koyama K, Murata Y, etal . EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue . Oncogene . 19 . 2 . 210–6 . 2000 . 10644998 . 10.1038/sj.onc.1203308 . 2284265 .
• Su LK, Qi Y . Characterization of human MAPRE genes and their proteins . Genomics . 71 . 2 . 142–9 . 2001 . 11161807 . 10.1006/geno.2000.6428 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Bu W, Su LK . Characterization of functional domains of human EB1 family proteins . J. Biol. Chem. . 278 . 50 . 49721–31 . 2004 . 14514668 . 10.1074/jbc.M306194200 . free .
• Douglas MW, Diefenbach RJ, Homa FL, etal . Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport . J. Biol. Chem. . 279 . 27 . 28522–30 . 2004 . 15117959 . 10.1074/jbc.M311671200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, etal . CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex . J. Cell Biol. . 168 . 1 . 141–53 . 2005 . 15631994 . 10.1083/jcb.200405094 . 2171674 .
• Yeh TY, Chuang JZ, Sung CH . Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway . J. Cell Sci. . 118 . Pt 15 . 3431–43 . 2005 . 16079286 . 10.1242/jcs.02472 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M . RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells . J Immunol . 159 . 3 . 1276–83 . Aug 1997 . 10.4049/jimmunol.159.3.1276 . 9233623 . 23797920 . free .
2. Web site: Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3.