MAPK12 explained

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.^[1]

Function

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.^[1]

Further reading

• Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G . Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. . J. Am. Chem. Soc. . 128 . 17 . 5913–22 . 2006 . 16637659 . 10.1021/ja060943h . 2533859.
• Joneson T, Bar-Sagi D . Ras effectors and their role in mitogenesis and oncogenesis. . J. Mol. Med. . 75 . 8 . 587–93 . 1997 . 9297626 . 10.1007/s001090050143. 23541383 .
• Hou SW, Zhi HY, Pohl N, etal . PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. . Cancer Res. . 70 . 7 . 2901–10 . 2010 . 20332238 . 10.1158/0008-5472.CAN-09-3229 . 2848905.
• Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, etal . Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I. . J. Gen. Virol. . 89 . Pt 7 . 1661–71 . 2008 . 18559936 . 10.1099/vir.0.82971-0 . free .
• Sabio G, Cerezo-Guisado MI, Del Reino P, etal . p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. . J. Cell Sci. . 123 . Pt 15 . 2596–604 . 2010 . 20605917 . 10.1242/jcs.066514 . 2908048.
• Zhang J, Harrison JS, Studzinski GP . Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃. . Exp. Cell Res. . 317 . 1 . 117–30 . 2011 . 20804750 . 10.1016/j.yexcr.2010.08.010 . 2998239.
• Kwong J, Hong L, Liao R, etal . p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms. . J. Biol. Chem. . 284 . 17 . 11237–46 . 2009 . 19251701 . 10.1074/jbc.M808327200 . 2670128. free .
• Morishima-Kawashima M, Hasegawa M, Takio K, etal . Hyperphosphorylation of tau in PHF. . Neurobiol. Aging . 16 . 3 . 365–71; discussion 371–80 . 1995. 7566346 . 10.1016/0197-4580(95)00027-C. 22471158 .
• Diskin R, Askari N, Capone R, etal . Active mutants of the human p38alpha mitogen-activated protein kinase. . J. Biol. Chem. . 279 . 45 . 47040–9 . 2004 . 15284239 . 10.1074/jbc.M404595200 . free .
• Askari N, Diskin R, Avitzour M, etal . Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription. . J. Biol. Chem. . 282 . 1 . 91–9 . 2007 . 17088247 . 10.1074/jbc.M608012200 . free .
• Krauss RS, Cole F, Gaio U, etal . Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. . J. Cell Sci. . 118 . Pt 11 . 2355–62 . 2005 . 15923648 . 10.1242/jcs.02397 . free .
• Talmud PJ, Drenos F, Shah S, etal . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. . Am. J. Hum. Genet. . 85 . 5 . 628–42 . 2009 . 19913121 . 10.1016/j.ajhg.2009.10.014 . 2775832.
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Tosti E, Waldbaum L, Warshaw G, etal . The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. . J. Biol. Chem. . 279 . 46 . 47652–60 . 2004 . 15342622 . 10.1074/jbc.M409961200 . free.
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Qi X, Pohl NM, Loesch M, etal . p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. . J. Biol. Chem. . 282 . 43 . 31398–408 . 2007 . 17724032 . 10.1074/jbc.M703857200 . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome. . Genome Biol. . 5 . 10 . R84 . 2004 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Kukkonen-Macchi A, Sicora O, Kaczynska K, etal . Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death. . J. Cell Sci. . 124 . Pt 2 . 216–27 . 2011 . 21172807 . 10.1242/jcs.068254 . 4909652 .
• William C. Mobley . Sofroniew MV, Howe CL, Mobley WC . Nerve growth factor signaling, neuroprotection, and neural repair. . Annu. Rev. Neurosci. . 24 . 1217–81 . 2001 . 11520933 . 10.1146/annurev.neuro.24.1.1217 .
• Bailey SD, Xie C, Do R, etal . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. . Diabetes Care . 33 . 10 . 2250–3 . 2010 . 20628086 . 10.2337/dc10-0452 . 2945168.

Notes and References

1. Web site: Entrez Gene: mitogen-activated protein kinase 12.