MAPK10 explained

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MAPK10 has been shown to interact with MAPK8IP3.^{[4] [5] [6]}

Further reading

• Freedman BD, Liu QH, Del Corno M, Collman RG . HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages . Immunol. Res. . 27 . 2–3 . 261–76 . 2003 . 12857973 . 10.1385/IR:27:2-3:261 . 32006625 .
• Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG . Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways . J. Leukoc. Biol. . 74 . 5 . 676–82 . 2003 . 12960231 . 10.1189/jlb.0503206 . 11362623 . free .
• Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR . Phosphorylation of c-jun mediated by MAP kinases . Nature . 353 . 6345 . 670–4 . 1991 . 1922387 . 10.1038/353670a0 . 1991Natur.353..670P . 29557176 .
• Mohit AA, Martin JH, Miller CA . p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system . Neuron . 14 . 1 . 67–78 . 1995 . 7826642 . 10.1016/0896-6273(95)90241-4 . 14107133 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C . gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes . Eur. J. Immunol. . 27 . 2 . 397–404 . 1997 . 9045910 . 10.1002/eji.1830270209 . 23787450 .
• Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA . Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene . Nature . 389 . 6653 . 865–70 . 1997 . 9349820 . 10.1038/39899 . 1997Natur.389..865Y . 4430535 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Hu MC, Qiu WR, Wang YP . JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases . Oncogene . 15 . 19 . 2277–87 . 1997 . 9393873 . 10.1038/sj.onc.1201401 . free .
• Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, Vincent JD, Tardieu M . Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neurons . Ann. Neurol. . 42 . 6 . 847–56 . 1997 . 9403476 . 10.1002/ana.410420605 . 36951375 .
• Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, Caron PR, Wilson KP, Su MS . Crystal structure of JNK3: a kinase implicated in neuronal apoptosis . Structure . 6 . 8 . 983–91 . 1998 . 9739089 . 10.1016/S0969-2126(98)00100-2 . free .
• Toward a complete human genome sequence . Genome Res. . 8 . 11 . 1097–108 . 1998 . 9847074 . 10.1101/gr.8.11.1097 . Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Koyano S, Ito M, Takamatsu N, Shiba T, Yamamoto K, Yoshioka K . A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1 . FEBS Lett. . 457 . 3 . 385–8 . 1999 . 10471813 . 10.1016/S0014-5793(99)01084-4 . 32690852 . free .
• Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI . JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway . Mol. Cell. Biol. . 19 . 11 . 7539–48 . 1999 . 10523642 . 84763 . 10.1128/mcb.19.11.7539.
• Kelkar N, Gupta S, Dickens M, Davis RJ . Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3 . Mol. Cell. Biol. . 20 . 3 . 1030–43 . 2000 . 10629060 . 85220 . 10.1128/MCB.20.3.1030-1043.2000 .
• Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P . Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1 . Biochemistry . 39 . 11 . 3141–8 . 2000 . 10715136 . 10.1021/bi992410 .
• McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ . Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3 . Science . 290 . 5496 . 1574–7 . 2000 . 11090355 . 10.1126/science.290.5496.1574 . 2000Sci...290.1574M .
• Pouysségur J . Signal transduction. An arresting start for MAPK . Science . 290 . 5496 . 1515–8 . 2000 . 11185509 . 10.1126/science.290.5496.1515 . 84778351 .
• Habelhah H, Shah K, Huang L, Ostareck-Lederer A, Burlingame AL, Shokat KM, Hentze MW, Ronai Z . ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation . Nat. Cell Biol. . 3 . 3 . 325–30 . 2001 . 11231586 . 10.1038/35060131 . 34298842 .

External links

• MAP Kinase Resource .

Notes and References

1. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, Davis RJ . Selective interaction of JNK protein kinase isoforms with transcription factors . EMBO J. . 15 . 11 . 2760–70 . July 1996 . 8654373 . 450211 . 10.1002/j.1460-2075.1996.tb00636.x.
2. Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M . Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene . J. Hum. Genet. . 47 . 11 . 614–9 . November 2002 . 12436199 . 10.1007/s100380200094 . free .
3. Web site: Entrez Gene: MAPK10 mitogen-activated protein kinase 10.
4. Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI . JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway . Mol. Cell. Biol. . 19 . 11 . 7539–48 . November 1999 . 10523642 . 84763 . 10.1128/mcb.19.11.7539.
5. Kelkar N, Gupta S, Dickens M, Davis RJ . Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3 . Mol. Cell. Biol. . 20 . 3 . 1030–43 . February 2000 . 10629060 . 85220 . 10.1128/MCB.20.3.1030-1043.2000 .
6. Matsuura H, Nishitoh H, Takeda K, Matsuzawa A, Amagasa T, Ito M, Yoshioka K, Ichijo H . Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade . J. Biol. Chem. . 277 . 43 . 40703–9 . October 2002 . 12189133 . 10.1074/jbc.M202004200 . free . 2297/2692 . free .