MINK1 explained

Misshapen-like kinase 1 is an enzyme that in humans is encoded by the MINK1 gene.^{[1] [2] [3]}

Function

Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.

Interactions

MINK1 has been shown to interact with NCK1.^[4]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants . Molecular Vision . 8 . 205–20 . Jun 2002 . 12107410 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nature Biotechnology . 21 . 5 . 566–9 . May 2003 . 12665801 . 10.1038/nbt810 . 23783563 .
• Campdelacreu J, Ezquerra M, Muñoz E, Oliva R, Tolosa E . Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy . Neuroscience Letters . 340 . 2 . 158–60 . Apr 2003 . 12668260 . 10.1016/S0304-3940(03)00105-8 . 45355312 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X . Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta . The Journal of Biological Chemistry . 279 . 52 . 54387–97 . Dec 2004 . 15469942 . 10.1074/jbc.M404497200 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Dan I, Watanabe NM, Kobayashi T, Yamashita-Suzuki K, Fukagaya Y, Kajikawa E, Kimura WK, Nakashima TM, Matsumoto K, Ninomiya-Tsuji J, Kusumi A . Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development . FEBS Letters . 469 . 1 . 19–23 . Mar 2000 . 10708748 . 10.1016/S0014-5793(00)01247-3 . 39793431 . free .
2. Dan I, Watanabe NM, Kajikawa E, Ishida T, Pandey A, Kusumi A . Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution . Nucleic Acids Research . 30 . 13 . 2906–10 . Jul 2002 . 12087176 . 117062 . 10.1093/nar/gkf407 .
3. Web site: Entrez Gene: MINK1 misshapen-like kinase 1 (zebrafish).
4. Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X . Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta . The Journal of Biological Chemistry . 279 . 52 . 54387–97 . Dec 2004 . 15469942 . 10.1074/jbc.M404497200 . free .