MAP4K3 explained

Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene.^[1]

Function

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Further reading

• Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM . MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins . Proc. Natl. Acad. Sci. U.S.A. . 106 . 29 . 11978–83 . 2009 . 19587239 . 2707271 . 10.1073/pnas.0900608106 . 2009PNAS..10611978L . free .
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip . Am. J. Hum. Genet. . 85 . 5 . 628–42 . 2009 . 19913121 . 2775832 . 10.1016/j.ajhg.2009.10.014 .
• Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ . Replication of previous genome-wide association studies of bone mineral density in premenopausal American women . J. Bone Miner. Res. . 25 . 8 . 1821–9 . 2010 . 20200978 . 3153352 . 10.1002/jbmr.62 .
• Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF . PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR . Mol. Cell . 37 . 5 . 633–42 . 2010 . 20227368 . 10.1016/j.molcel.2010.01.031 . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S . Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study . Diabetes Care . 33 . 10 . 2250–3 . 2010 . 20628086 . 2945168 . 10.2337/dc10-0452 .
• Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH . The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells . Nat. Immunol. . 12 . 11 . 1113–8 . 2011 . 21983831 . 10.1038/ni.2121 . 205364658 .
• Chen DY, Chuang HC, Lan JL, Chen YM, Hung WT, Lai KL, Tan TH . Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker . BMC Med . 10 . 84 . 2012 . 22867055 . 3424974 . 10.1186/1741-7015-10-84 . free .
• Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R . Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism . J. Nutr. Biochem. . 24 . 5 . 824–31 . 2013 . 22898570 . 10.1016/j.jnutbio.2012.04.018 .

Notes and References

1. Web site: Entrez Gene: Mitogen-activated protein kinase kinase kinase kinase 3. 2017-09-22.