MAP3K7IP3 explained

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[1] [2] [3]

Function

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

Interactions

MAP3K7IP3 has been shown to interact with MAP3K7IP2, TAB1 and MAP3K7.[1] [2]

Further reading

Notes and References

  1. Richard Gaynor. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K . Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling . EMBO J . 22 . 23 . 6277–88 . Nov 2003 . 14633987 . 291846 . 10.1093/emboj/cdg605 .
  2. Cheung PC, Nebreda AR, Cohen P . TAB3, a new binding partner of the protein kinase TAK1 . Biochem J . 378 . Pt 1 . 27–34 . Feb 2004 . 14670075 . 1223947 . 10.1042/BJ20031794 .
  3. Web site: Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3.