MAP3K7IP3 explained
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[1] [2] [3]
Function
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
Interactions
MAP3K7IP3 has been shown to interact with MAP3K7IP2, TAB1 and MAP3K7.[1] [2]
Further reading
- Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
- Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B . Identification of a human NF-kappaB-activating protein, TAB3. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 7 . 2028–33 . 2004 . 14766965 . 357046 . 10.1073/pnas.0307314101 . 2004PNAS..101.2028J . free .
- Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ . TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. . Mol. Cell . 15 . 4 . 535–48 . 2004 . 15327770 . 10.1016/j.molcel.2004.08.008 . free .
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG . TAK1-dependent signaling requires functional interaction with TAB2/TAB3. . J. Biol. Chem. . 282 . 6 . 3918–28 . 2007 . 17158449 . 3197015 . 10.1074/jbc.M608867200 . free .
Notes and References
- Richard Gaynor. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K . Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling . EMBO J . 22 . 23 . 6277–88 . Nov 2003 . 14633987 . 291846 . 10.1093/emboj/cdg605 .
- Cheung PC, Nebreda AR, Cohen P . TAB3, a new binding partner of the protein kinase TAK1 . Biochem J . 378 . Pt 1 . 27–34 . Feb 2004 . 14670075 . 1223947 . 10.1042/BJ20031794 .
- Web site: Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3.
