MAP3K10 explained

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Interactions

MAP3K10 has been shown to interact with:

• CDC42,
• Huntingtin,^[4]
• KIF3A,^[5]
• MAPK8IP1,^[6]
• MAPK8IP2,^[6] and
• NEUROD1.^[7]

Further reading

• Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ . Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity . J. Biol. Chem. . 269 . 21 . 15092–100 . 1994 . 10.1016/S0021-9258(17)36578-X . 8195146 . free .
• Dorow DS, Devereux L, Dietzsch E, De Kretser T . Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains . Eur. J. Biochem. . 213 . 2 . 701–10 . 1993 . 8477742 . 10.1111/j.1432-1033.1993.tb17810.x . free .
• ((Hirai Si)), Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J, Ohno S . MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase . J. Biol. Chem. . 272 . 24 . 15167–73 . 1997 . 9182538 . 10.1074/jbc.272.24.15167 . free .
• ((Hirai Si)), Noda K, Moriguchi T, Nishida E, Yamashita A, Deyama T, Fukuyama K, Ohno S . Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2 . J. Biol. Chem. . 273 . 13 . 7406–12 . 1998 . 9516438 . 10.1074/jbc.273.13.7406 . free .
• Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS . Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins . Electrophoresis . 19 . 5 . 809–17 . 1998 . 9629920 . 10.1002/elps.1150190535 . 21204230 .
• Rasmussen RK, Rusak J, Price G, Robinson PJ, Simpson RJ, Dorow DS . Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid . Biochem. J. . 335 . Pt 1 . 119–24 . 1998 . 9742220 . 1219759 . 10.1042/bj3350119.
• Liu YF, Dorow D, Marshall J . Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin . J. Biol. Chem. . 275 . 25 . 19035–40 . 2000 . 10801775 . 10.1074/jbc.C000180200 . free .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
• Savinainen A, Garcia EP, Dorow D, Marshall J, Liu YF . Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95 . J. Biol. Chem. . 276 . 14 . 11382–6 . 2001 . 11152698 . 10.1074/jbc.M100190200 . free .
• Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA . The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis . Mol. Cell. Biol. . 21 . 14 . 4713–24 . 2001 . 11416147 . 87148 . 10.1128/MCB.21.14.4713-4724.2001 .
• Poy MN, Yang Y, Rezaei K, Fernström MA, Lee AD, Kido Y, Erickson SK, Najjar SM . CEACAM1 regulates insulin clearance in liver . Nat. Genet. . 30 . 3 . 270–6 . 2002 . 11850617 . 10.1038/ng840 . 30473455 .
• Akbarzadeh S, Ji H, Frecklington D, Marmy-Conus N, Mok YF, Bowes L, Devereux L, Linsenmeyer M, Simpson RJ, Dorow DS . Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking . J. Biol. Chem. . 277 . 39 . 36280–7 . 2002 . 12105200 . 10.1074/jbc.M204626200 . free .
• Figueroa C, Tarras S, Taylor J, Vojtek AB . Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex . J. Biol. Chem. . 278 . 48 . 47922–7 . 2004 . 14504284 . 10.1074/jbc.M307357200 . free .
• Eckey M, Tenbaum SP, Muñoz A, Baniahmad A . Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors . Mol. Cell. Endocrinol. . 213 . 1 . 71–8 . 2004 . 15062575 . 10.1016/j.mce.2003.10.035 . 38167719 .
• Jaffe AB, Hall A, Schmidt A . Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho . Curr. Biol. . 15 . 5 . 405–12 . 2005 . 15753034 . 10.1016/j.cub.2004.12.082 . 16479940 . free . 2005CBio...15..405J .
• Kollers S, Musilova P, Rubes J, Rocha D . Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13 . Anim. Genet. . 37 . 6 . 595–6 . 2007 . 17121608 . 10.1111/j.1365-2052.2006.01516.x .

Notes and References

1. Dorow DS, Devereux L, Tu GF, Price G, Nicholl JK, Sutherland GR, Simpson RJ . Grant Robert Sutherland . Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2 . Eur J Biochem . 234 . 2 . 492–500 . February 1996 . 8536694 . 10.1111/j.1432-1033.1995.492_b.x .
2. Katoh M, Hirai M, Sugimura T, Terada M . Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain . Oncogene . 10 . 7 . 1447–51 . May 1995 . 7731697 .
3. Web site: Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10.
4. Liu YF, Dorow D, Marshall J . Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin . J. Biol. Chem. . 275 . 25 . 19035–40 . June 2000 . 10801775 . 10.1074/jbc.C000180200 . free .
5. ((Nagata Ki)), Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A . The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 . EMBO J. . 17 . 1 . 149–58 . January 1998 . 9427749 . 1170366 . 10.1093/emboj/17.1.149 .
6. Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ . The JIP group of mitogen-activated protein kinase scaffold proteins . Mol. Cell. Biol. . 19 . 10 . 7245–54 . October 1999 . 10490659 . 84717 . 10.1128/mcb.19.10.7245.
7. Marcora E, Gowan K, Lee JE . Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 . Proc. Natl. Acad. Sci. U.S.A. . 100 . 16 . 9578–83 . August 2003 . 12881483 . 170960 . 10.1073/pnas.1133382100 . 2003PNAS..100.9578M . free .