MAN1B1 explained

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.^{[1] [2] [3]}

Further reading

• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum. . Biochimie . 83 . 8 . 783–90 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Dedera DA, Gu RL, Ratner L . Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function. . Virology . 187 . 1 . 377–82 . 1992 . 1736542 . 10.1016/0042-6822(92)90331-I .
• Kalyanaraman VS, Rodriguez V, Veronese F, etal . Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1. . AIDS Res. Hum. Retroviruses . 6 . 3 . 371–80 . 1990 . 2187500 . 10.1089/aid.1990.6.371 .
• Shimizu H, Tsuchie H, Honma H, etal . Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins. . Jpn. J. Med. Sci. Biol. . 43 . 3 . 75–87 . 1991 . 2283726 . 10.7883/yoken1952.43.75. free .
• Leonard CK, Spellman MW, Riddle L, etal . Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. . J. Biol. Chem. . 265 . 18 . 10373–82 . 1990 . 10.1016/S0021-9258(18)86956-3 . 2355006 . free .
• Stein BS, Engleman EG . Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex. . J. Biol. Chem. . 265 . 5 . 2640–9 . 1990 . 10.1016/S0021-9258(19)39849-7 . 2406237 . free .
• Pal R, Hoke GM, Sarngadharan MG . Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1. . Proc. Natl. Acad. Sci. U.S.A. . 86 . 9 . 3384–8 . 1989 . 2541446 . 10.1073/pnas.86.9.3384 . 287137 . 1989PNAS...86.3384P . free .
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP . Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport. . J. Virol. . 63 . 6 . 2452–6 . 1989 . 2542563 . 10.1128/jvi.63.6.2452-2456.1989. 250699 .
• Kozarsky K, Penman M, Basiripour L, etal . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein. . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–9 . 1989 . 2649653 .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis. . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–82 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Blough HA, Pauwels R, De Clercq E, etal . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins. . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–8 . 1987 . 3099781 . 10.1016/S0006-291X(86)80330-8 .
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1. . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–52 . 1988 . 3264072 . 10.1073/pnas.85.23.9248 . 282716 . 1988PNAS...85.9248M . free .
• Fenouillet E, Jones I, Powell B, etal . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain. . J. Virol. . 67 . 1 . 150–60 . 1993 . 8093218 . 10.1128/jvi.67.1.150-160.1993. 237347 .
• Yeh JC, Seals JR, Murphy CI, etal . Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system. . Biochemistry . 32 . 41 . 11087–99 . 1993 . 8218172 . 10.1021/bi00092a019 .
• Bolmstedt A, Sjölander S, Hansen JE, etal . Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response. . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 12 . 3 . 213–20 . 1996 . 8673525 . 10.1097/00042560-199607000-00001. free .
• Hu H, Shioda T, Moriya C, etal . Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface. . J. Virol. . 70 . 11 . 7462–70 . 1996 . 8892864 . 10.1128/jvi.70.11.7462-7470.1996. 190813 .
• Papandreou MJ, Fenouillet E . Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation. . FEBS Lett. . 406 . 1–2 . 191–5 . 1997 . 9109416 . 10.1016/S0014-5793(97)00273-1 . 17660 . free .
• Tremblay LO, Campbell Dyke N, Herscovics A . Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation. . Glycobiology . 8 . 6 . 585–95 . 1998 . 9592125 . 10.1093/glycob/8.6.585 . free .

Notes and References

1. Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW . Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis . J Biol Chem . 274 . 30 . 21375–86 . Aug 1999 . 10409699 . 10.1074/jbc.274.30.21375 . free .
2. Tremblay LO, Herscovics A . Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis . Glycobiology . 9 . 10 . 1073–8 . Nov 1999 . 10521544 . 10.1093/glycob/9.10.1073 . free .
3. Web site: Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1.