MAN1A2 explained

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB is an enzyme that in humans is encoded by the MAN1A2 gene.^{[1] [2]}

Further reading

• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum. . Biochimie . 83 . 8 . 783–790 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–321 . 2006 . 16710414 . 10.1038/nature04727 . vanc. Barlow KF . McLay KE . 3 . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Colland F . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–1332 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . vanc. Jacq X . Trouplin V . 3 . Mougin . C . Groizeleau . C . Hamburger . A . Meil . A . Wojcik . J . Legrain . P .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Hart ML, Saifuddin M, Spear GT . Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin . J. Gen. Virol. . 84 . Pt 2 . 353–360 . 2003 . 12560567 . 10.1099/vir.0.18734-0 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Papandreou MJ, Fenouillet E . Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation . FEBS Lett. . 406 . 1–2 . 191–195 . 1997 . 9109416 . 10.1016/S0014-5793(97)00273-1 . 17660 . free .
• Hu H . Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface . J. Virol. . 70 . 11 . 7462–7470 . 1996 . 8892864 . 10.1128/jvi.70.11.7462-7470.1996. 190813 . vanc. Shioda T . Moriya C . 3 . Xin . X . Hasan . MK . Miyake . K . Shimada . T . Nagai . Y .
• Bolmstedt A . Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 12 . 3 . 213–220 . 1996 . 8673525 . 10.1097/00042560-199607000-00001 . vanc. Sjölander S . Hansen JE . 3 . Åkerblom . Lennart . Hemming . Anna . Hu . Shiu-Lok . Morein . Bror . Olofsson . Sigvard. free .
• Yeh JC . Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system . Biochemistry . 32 . 41 . 11087–11099 . 1993 . 8218172 . 10.1021/bi00092a019 . vanc. Seals JR . Murphy CI . 3 . Van Halbeek . Herman . Cummings . Richard D. .
• Fenouillet E . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain . J. Virol. . 67 . 1 . 150–160 . 1993 . 8093218 . 10.1128/jvi.67.1.150-160.1993. 237347 . vanc. Jones I . Powell B . 3 . Schmitt . D . Kieny . MP . Gluckman . JC .
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–9252 . 1988 . 3264072 . 10.1073/pnas.85.23.9248 . 282716 . 1988PNAS...85.9248M . free .
• Blough HA . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–38 . 1987 . 3099781 . 10.1016/S0006-291X(86)80330-8 . vanc. Pauwels R . De Clercq E . 3 . Cogniaux . J. . Sprecher-Goldberger . S. . Thiry . L. .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–282 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Kozarsky K . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–169 . 1989 . 2649653 . vanc. Penman M . Basiripour L . 3 . Haseltine . W . Sodroski . J . Krieger . M .
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP . Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport . J. Virol. . 63 . 6 . 2452–2456 . 1989 . 2542563 . 10.1128/jvi.63.6.2452-2456.1989. 250699 .

Notes and References

1. Tremblay LO, Campbell Dyke N, Herscovics A . Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation . Glycobiology . 8 . 6 . 585–595 . Jul 1998 . 9592125 . 10.1093/glycob/8.6.585 . free .
2. Web site: Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2.