MAN1A1 explained

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene.^{[1] [2]}

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the removal of 3 distinct mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases.

Further reading

• Land A, Braakman I . Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum . Biochimie . 83 . 8 . 783–90 . 2001 . 11530211 . 10.1016/S0300-9084(01)01314-1 . 1874/5091 . 13576808 . free .
• Dedera DA, Gu RL, Ratner L . Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function . Virology . 187 . 1 . 377–82 . 1992 . 1736542 . 10.1016/0042-6822(92)90331-I .
• Kalyanaraman VS . Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 . AIDS Res. Hum. Retroviruses . 6 . 3 . 371–80 . 1990 . 2187500 . 10.1089/aid.1990.6.371 . vanc. Rodriguez V . Veronese F . 3 . Rahman . R. . Lusso . P. . Devico . A.L. . Copeland . T. . Oroszlan . S. . Gallo . R.C. .
• Shimizu H . Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins . Jpn. J. Med. Sci. Biol. . 43 . 3 . 75–87 . 1991 . 2283726 . 10.7883/yoken1952.43.75. vanc. Tsuchie H . Honma H . 3 . Yoshida . K . Tsuruoka . T . Ushijima . H . Kitamura . T . free .
• Leonard CK . Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells . J. Biol. Chem. . 265 . 18 . 10373–82 . 1990 . 2355006 . vanc. Spellman MW . Riddle L . 3 . Harris . RJ . Thomas . JN . Gregory . TJ . 10.1016/S0021-9258(18)86956-3 . free .
• Stein BS, Engleman EG . Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex . J. Biol. Chem. . 265 . 5 . 2640–9 . 1990 . 10.1016/S0021-9258(19)39849-7 . 2406237 . free .
• Pal R, Hoke GM, Sarngadharan MG . Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 86 . 9 . 3384–8 . 1989 . 2541446 . 10.1073/pnas.86.9.3384 . 287137 . 1989PNAS...86.3384P . free .
• Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP . Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport . J. Virol. . 63 . 6 . 2452–6 . 1989 . 2542563 . 10.1128/JVI.63.6.2452-2456.1989. 250699 .
• Kozarsky K . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–9 . 1989 . 2649653 . vanc. Penman M . Basiripour L . 3 . Haseltine . W . Sodroski . J . Krieger . M .
• Robinson WE, Montefiori DC, Mitchell WM . Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis . AIDS Res. Hum. Retroviruses . 3 . 3 . 265–82 . 1988 . 2829950 . 10.1089/aid.1987.3.265 .
• Blough HA . Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins . Biochem. Biophys. Res. Commun. . 141 . 1 . 33–8 . 1987 . 3099781 . 10.1016/S0006-291X(86)80330-8 . vanc. Pauwels R . De Clercq E . 3 . Cogniaux . J. . Sprecher-Goldberger . S. . Thiry . L. .
• Montefiori DC, Robinson WE, Mitchell WM . Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 . Proc. Natl. Acad. Sci. U.S.A. . 85 . 23 . 9248–52 . 1988 . 3264072 . 10.1073/pnas.85.23.9248 . 282716 . 1988PNAS...85.9248M . free .
• Bieberich E, Bause E . Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein . Eur. J. Biochem. . 233 . 2 . 644–9 . 1995 . 7588811 . 10.1111/j.1432-1033.1995.644_2.x . free .
• Fenouillet E . Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain . J. Virol. . 67 . 1 . 150–60 . 1993 . 8093218 . 10.1128/JVI.67.1.150-160.1993. 237347 . vanc. Jones I . Powell B . 3 . Schmitt . D . Kieny . MP . Gluckman . JC .
• Yeh JC . Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system . Biochemistry . 32 . 41 . 11087–99 . 1993 . 8218172 . 10.1021/bi00092a019 . vanc. Seals JR . Murphy CI . 3 . Van Halbeek . Herman . Cummings . Richard D. .
• Bolmstedt A . Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response . J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. . 12 . 3 . 213–20 . 1996 . 8673525 . 10.1097/00042560-199607000-00001 . vanc. Sjölander S . Hansen JE . 3 . Åkerblom . Lennart . Hemming . Anna . Hu . Shiu-Lok . Morein . Bror . Olofsson . Sigvard. free .
• Hu H . Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface . J. Virol. . 70 . 11 . 7462–70 . 1996 . 8892864 . 10.1128/JVI.70.11.7462-7470.1996. 190813 . vanc. Shioda T . Moriya C . 3 . Xin . X . Hasan . MK . Miyake . K . Shimada . T . Nagai . Y .
• Papandreou MJ, Fenouillet E . Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation . FEBS Lett. . 406 . 1–2 . 191–5 . 1997 . 9109416 . 10.1016/S0014-5793(97)00273-1 . 17660 . free .
• Bieberich E . Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells . Eur. J. Biochem. . 246 . 3 . 681–9 . 1997 . 9219526 . 10.1111/j.1432-1033.1997.t01-1-00681.x . vanc. Treml K . Völker C . 3 . Rolfs . Andreas . Kalz-Fuller . Burga . Bause . Ernst . free .

Notes and References

1. Bause E, Bieberich E, Rolfs A, Volker C, Schmidt B . Molecular cloning and primary structure of Man9-mannosidase from human kidney . Eur J Biochem . 217 . 2 . 535–40 . Dec 1993 . 8223597 . 10.1111/j.1432-1033.1993.tb18274.x . free .
2. Web site: Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1.