MAM domain explained

MAM domain is an evolutionary conserved protein domain. It is an extracellular domain found in many receptors.

A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins.^[1] These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein);^[2] A5 antigen (a developmentally-regulated cell surface protein; Xenopus nrp1;);^[3] and receptor-like tyrosine protein phosphatase.^[4] The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.

Human proteins containing this domain

ALK

EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2; MEP1A; MEP1B; NPNT

NRP1; NRP2; PRSS7; PTPRK; PTPRM; PTPRO; PTPRT; PTPRU

ZAN

Notes and References

1. Bork P, Beckmann G . An adhesive domain detected in functionally diverse receptors . Trends Biochem. Sci. . 18 . 2 . 40–41 . 1993 . 8387703 . 10.1016/0968-0004(93)90049-s.
2. Grant GA, Jiang W, Gorbea CM, Flannery AV, Beynon RJ, Bond JS . The alpha subunit of meprin A. Molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the alpha and beta subunits . J. Biol. Chem. . 267 . 13 . 9185–9193 . 1992 . 1374387.
3. Takagi S, Hirata T, Agata K, Eguchi G, Fujisawa H, Mochii M . The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors . Neuron . 7 . 2 . 295–307 . 1991 . 1908252 . 10.1016/0896-6273(91)90268-5. 11355150 .
4. Gebbink MF, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Moolenaar WH, van Etten I, Geurts van Kessel A . Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase . FEBS Lett. . 290 . 1 . 123–130 . 1991 . 1655529 . 10.1016/0014-5793(91)81241-Y. 7237197 . free .