MAML2 explained

Mastermind-like protein 2 is a protein that in humans is encoded by the MAML2 gene.^{[1] [2] [3]}

See also

Details on the activity of the N-terminal domain of Mastermind-like protein 2 may be found under MamL-1.

Further reading

• Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 8 . 2 . 85–95 . 2001 . 11347906 . 10.1093/dnares/8.2.85 . free .
• Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ . t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. . Nat. Genet. . 33 . 2 . 208–13 . 2003 . 12539049 . 10.1038/ng1083 . 23417795 .
• Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G . Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. . Exp. Cell Res. . 292 . 1 . 21–8 . 2004 . 14720503 . 10.1016/j.yexcr.2003.09.007 .
• Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G . Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. . Genes Chromosomes Cancer . 43 . 2 . 202–5 . 2005 . 15729701 . 10.1002/gcc.20168 . 39267344 .
• Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD . Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. . EMBO J. . 24 . 13 . 2391–402 . 2005 . 15961999 . 1173159 . 10.1038/sj.emboj.7600719 .
• Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H . MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. . Clin. Cancer Res. . 12 . 13 . 3902–7 . 2007 . 16818685 . 10.1158/1078-0432.CCR-05-2376 . free .
• Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G . Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. . Genes Chromosomes Cancer . 46 . 6 . 559–63 . 2007 . 17334997 . 10.1002/gcc.20440 . 39594598 . free .
• Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK . CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. . Genes Chromosomes Cancer . 46 . 7 . 708–15 . 2007 . 17437281 . 10.1002/gcc.20458 . 24634433 .
• Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T . Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). . Genes Chromosomes Cancer . 46 . 9 . 813–9 . 2007 . 17551948 . 10.1002/gcc.20467 . 42629564 . free .

Notes and References

1. Wu L, Sun T, Kobayashi K, Gao P, Griffin JD . Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors . Mol Cell Biol . 22 . 21 . 7688–700 . Oct 2002 . 12370315 . 135662 . 10.1128/MCB.22.21.7688-7700.2002 .
2. Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M . Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling . J Biol Chem . 277 . 52 . 50612–20 . Dec 2002 . 12386158 . 10.1074/jbc.M209529200 . free .
3. Web site: Entrez Gene: MAML2 mastermind-like 2 (Drosophila).