MALL explained

MAL-like protein is a protein that in humans is encoded by the MALL gene.^{[1] [2]}

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid-enriched membrane (GEM) and cholesterol-enriched membrane rafts. It interacts with caveolin-1.

Further reading

• Kurdina MI, Denisov LE . [An evaluation of the efficacy of dispensary care as a method for the active detection of skin melanoma] . Klinicheskaia Meditsina . 70 . 11–12 . 68–70 . 1993 . 1294831 .
• Lautner-Rieske A, Thiebe R, Zachau HG . Searching for non-V kappa transcripts from the human immunoglobulin kappa locus . Gene . 159 . 2 . 199–202 . 1995 . 7622049 . 10.1016/0378-1119(95)00161-X .
• Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U . Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family . Gene . 189 . 2 . 269–75 . 1997 . 9168137 . 10.1016/S0378-1119(96)00861-X .
• Saunier S . A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis . Hum. Mol. Genet. . 6 . 13 . 2317–23 . 1998 . 9361039 . 10.1093/hmg/6.13.2317 . vanc. Calado J . Heilig R . 3 . Silbermann . F . Benessy . F . Morin . G . Konrad . M . Broyer . M . Gubler . MC . free .
• de Marco MC . BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells . J. Biol. Chem. . 276 . 25 . 23009–17 . 2001 . 11294831 . 10.1074/jbc.M009739200 . vanc. Kremer L . Albar JP . 3 . Martinez-Menarguez . JA . Ballesta . J . Garcia-Lopez . MA . Marazuela . M . Puertollano . R . Alonso . MA . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Hildebrandt F, Otto E, Rensing C, Nothwang HG, Vollmer M, Adolphs J, Hanusch H, Brandis M . A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1 . Nat Genet . 17 . 2 . 149–53 . Nov 1997 . 9326933 . 10.1038/ng1097-149 . 38035697 .
2. Web site: Entrez Gene: MALL mal, T-cell differentiation protein-like.