MAL2 (gene) explained

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.^{[1] [2]}

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.^[3]

Interactions

MAL2 (gene) has been shown to interact with TPD52.

Further reading

• Marazuela M, Alonso MA . Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue . Histol. Histopathol. . 19 . 3 . 925–33 . 2004 . 15168355 .
• Rohan S, Tu JJ, Kao J, etal . Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes . Clin. Cancer Res. . 12 . 23 . 6937–45 . 2007 . 17145811 . 10.1158/1078-0432.CCR-06-1268 . free .
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA . Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations . Leuk. Res. . 30 . 11 . 1355–63 . 2007 . 16620967 . 10.1016/j.leukres.2006.03.009 .
• de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA . Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells . Traffic . 7 . 1 . 61–73 . 2006 . 16445687 . 10.1111/j.1600-0854.2005.00361.x . 44752098 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Llorente A, de Marco MC, Alonso MA . Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line . J. Cell Sci. . 117 . Pt 22 . 5343–51 . 2005 . 15466889 . 10.1242/jcs.01420 . free .
• Marazuela M, Acevedo A, García-López MA, etal . Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia . J. Histochem. Cytochem. . 52 . 2 . 243–52 . 2004 . 14729876 . 10.1177/002215540405200212. free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Marazuela M, Martín-Belmonte F, García-López MA, etal . Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells . Endocrinology . 145 . 2 . 1011–6 . 2004 . 14576188 . 10.1210/en.2003-0652 . free .
• Boutros R, Bailey AM, Wilson SH, Byrne JA . Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins . J. Mol. Biol. . 332 . 3 . 675–87 . 2003 . 12963375 . 10.1016/S0022-2836(03)00944-6 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• de Marco MC, Martín-Belmonte F, Kremer L, etal . MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells . J. Cell Biol. . 159 . 1 . 37–44 . 2002 . 12370246 . 10.1083/jcb.200206033 . 2173496 .

Notes and References

1. Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA . Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system . Genomics . 76 . 1–3 . 81–8 . Sep 2001 . 11549320 . 10.1006/geno.2001.6610 .
2. Web site: Entrez Gene: MAL2 mal, T-cell differentiation protein 2.
3. Web site: Entrez Gene: MAL2 mal, T-cell differentiation protein 2.