MAGOH explained

Protein mago nashi homolog is a human protein encoded by the MAGOH gene.^{[1] [2]} This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the germplasm, but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

In Drosophila

Drosophila flies produce unfit progeny when they have mutations in their gene. The progeny have defects in germplasm assembly and germline development.

Interactions

MAGOH interacts with RBM8A^{[3] [4]} and NXF1.^[4]

In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 are core components of the exon junction complex. They complex with novel zinc finger protein Ranshi, which is involved in oocyte differentiation.^[5]

Further reading

• Newmark PA, Mohr SE, Gong L, Boswell RE . mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila . Development . 124 . 16 . 3197–207 . 1997 . 10.1242/dev.124.16.3197 . 9272960 . free .
• Zhao XF, Nowak NJ, Shows TB, Aplan PD . MAGOH interacts with a novel RNA-binding protein . Genomics . 63 . 1 . 145–8 . 2000 . 10662555 . 10.1006/geno.1999.6064 .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Mingot JM, Kostka S, Kraft R, etal . Importin 13: a novel mediator of nuclear import and export . EMBO J. . 20 . 14 . 3685–94 . 2001 . 11447110 . 10.1093/emboj/20.14.3685 . 125545 .
• Hachet O, Ephrussi A . Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport . Curr. Biol. . 11 . 21 . 1666–74 . 2002 . 11696323 . 10.1016/S0960-9822(01)00508-5 . 2373806 . free .
• Kataoka N, Diem MD, Kim VN, etal . Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex . EMBO J. . 20 . 22 . 6424–33 . 2002 . 11707413 . 10.1093/emboj/20.22.6424 . 125744 .
• Jurica MS, Licklider LJ, Gygi SR, etal . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Fribourg S, Gatfield D, Izaurralde E, Conti E . A novel mode of RBD-protein recognition in the Y14-Mago complex . Nat. Struct. Biol. . 10 . 6 . 433–9 . 2003 . 12730685 . 10.1038/nsb926 . 40116577 .
• Lau CK, Diem MD, Dreyfuss G, Van Duyne GD . Structure of the Y14-Magoh core of the exon junction complex . Curr. Biol. . 13 . 11 . 933–41 . 2004 . 12781131 . 10.1016/S0960-9822(03)00328-2 . 14752714 . free .
• Chan CC, Dostie J, Diem MD, etal . eIF4A3 is a novel component of the exon junction complex . RNA . 10 . 2 . 200–9 . 2004 . 14730019 . 10.1261/rna.5230104 . 1370532 .
• Palacios IM, Gatfield D, St Johnston D, Izaurralde E . An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay . Nature . 427 . 6976 . 753–7 . 2004 . 14973490 . 10.1038/nature02351 . 2004Natur.427..753P . 4400243 .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ballut L, Marchadier B, Baguet A, etal . The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity . Nat. Struct. Mol. Biol. . 12 . 10 . 861–9 . 2005 . 16170325 . 10.1038/nsmb990 . 1359792 .
• Gehring NH, Kunz JB, Neu-Yilik G, etal . Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements . Mol. Cell . 20 . 1 . 65–75 . 2005 . 16209946 . 10.1016/j.molcel.2005.08.012 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Andersen CB, Ballut L, Johansen JS, etal . Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA . Science . 313 . 5795 . 1968–72 . 2006 . 16931718 . 10.1126/science.1131981 . 2006Sci...313.1968A . 26409491 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Quaresma AJ, Sievert R, Nickerson JA . Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway. . Mol. Biol. Cell . 24. 8. 1208–21 . 2013 . 23427269 . 10.1091/mbc.E12-06-0450 . 3623641 .

Notes and References

1. Zhao XF, Colaizzo-Anas T, Nowak NJ, Shows TB, Elliott RW, Aplan PD . The mammalian homologue of mago nashi encodes a serum-inducible protein . Genomics . 47 . 2 . 319–22 . April 1998 . 9479507 . 10.1006/geno.1997.5126 .
2. Web site: Entrez Gene: MAGOH mago-nashi homolog, proliferation-associated (Drosophila).
3. Zhao . X F . Nowak N J . Shows T B . Aplan P D . January 2000 . MAGOH interacts with a novel RNA-binding protein . Genomics . 63 . 1 . 145–8 . UNITED STATES. 0888-7543. 10662555 . 10.1006/geno.1999.6064 .
4. Kataoka . N . Diem M D . Kim V N . Yong J . Dreyfuss G . November 2001 . Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex . EMBO J. . 20 . 22 . 6424–33 . England. 0261-4189. 11707413 . 10.1093/emboj/20.22.6424 . 125744 .
5. Lewandowski JP, Sheehan KB, Bennett PE Jr, Boswell RE . Mar 2010 . Mago Nashi, Tsunagi/Y14, and Ranshi form a complex that influences oocyte differentiation in Drosophila melanogaster. Dev. Biol. . 339 . 2. 307–19 . 10.1016/j.ydbio.2009.12.035 . 20045686 . 2852135 .