MAGI3 explained

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.^{[1] [2] [3]}

Interactions

MAGI3 has been shown to interact with PTPRB^[4] and PTEN.

Further reading

• Zhang H, Wang D, Sun H, etal . MAGI-3 regulates LPA-induced activation of Erk and RhoA. . Cell. Signal. . 19 . 2 . 261–8 . 2007 . 16904289 . 10.1016/j.cellsig.2006.06.008 . 1995035 .
• He J, Bellini M, Inuzuka H, etal . Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. . J. Biol. Chem. . 281 . 5 . 2820–7 . 2006 . 16316992 . 10.1074/jbc.M509503200 . free .
• Franklin JL, Yoshiura K, Dempsey PJ, etal . Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. . Exp. Cell Res. . 303 . 2 . 457–70 . 2005 . 15652357 . 10.1016/j.yexcr.2004.10.007 .
• Yao R, Natsume Y, Noda T . MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. . Oncogene . 23 . 36 . 6023–30 . 2005 . 15195140 . 10.1038/sj.onc.1207817 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Adamsky K, Arnold K, Sabanay H, Peles E . Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. . J. Cell Sci. . 116 . Pt 7 . 1279–89 . 2003 . 12615970 . 10.1242/jcs.00302 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nakayama M, Kikuno R, Ohara O . Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. . Genome Res. . 12 . 11 . 1773–84 . 2003 . 12421765 . 10.1101/gr.406902 . 187542 .
• Thomas M, Laura R, Hepner K, etal . Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. . Oncogene . 21 . 33 . 5088–96 . 2002 . 12140759 . 10.1038/sj.onc.1205668 . free .
• Laura RP, Ross S, Koeppen H, Lasky LA . MAGI-1: a widely expressed, alternatively spliced tight junction protein. . Exp. Cell Res. . 275 . 2 . 155–70 . 2002 . 11969287 . 10.1006/excr.2002.5475 .

Notes and References

1. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 4 . 273–81 . Dec 2000 . 10997877 . 10.1093/dnares/7.4.271. free .
2. Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA . Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase . J Biol Chem . 275 . 28 . 21477–85 . Aug 2000 . 10748157 . 10.1074/jbc.M909741199 . free .
3. Web site: Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3.
4. 10.1242/jcs.00302 . Adamsky . Konstantin . Arnold Katya . Sabanay Helena . Peles Elior . Apr 2003 . Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins . J. Cell Sci. . 116 . Pt 7 . 1279–89 . 0021-9533. 12615970 . free .