MAGED4B explained

Melanoma-associated antigen D4 is a protein that in humans is encoded by the MAGED4B gene.^[1]

This gene is related to members of the MAGED gene family, in terms of the sequence similarity and the chromosome location. This gene is expressed only in brain and ovary among normal tissues, and two transcript variants of this gene are specifically expressed in glioma cells among cancer cells. This gene and the other MAGED genes are clustered on chromosome Xp11. Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined.^[1]

Further reading

• Nakajima D, Okazaki N, Yamakawa H, etal . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Nagase T, Nakayama M, Nakajima D, etal . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 8 . 2 . 85–95 . 2001 . 11347906 . 10.1093/dnares/8.2.85 . free .
• Sasaki M, Nakahira K, Kawano Y, etal . MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. . Cancer Res. . 61 . 12 . 4809–14 . 2001 . 11406556 .
• Kawano Y, Sasaki M, Nakahira K, etal . Structural characterization and chromosomal localization of the MAGE-E1 gene. . Gene . 277 . 1–2 . 129–37 . 2001 . 11602350 . 10.1016/S0378-1119(01)00698-9 . 2433/149322 . 19474178 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ito S, Kawano Y, Katakura H, etal . Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. . Lung Cancer . 51 . 1 . 79–88 . 2006 . 16225959 . 10.1016/j.lungcan.2005.08.012 . 2433/143846 . free .

Notes and References

1. Web site: MAGED4B MAGE family member D4B [Homo sapiens (human)]]. National Center for Biotechnology Information. 28 September 2020.