MAGED2 explained

Melanoma-associated antigen D2 is a protein that in humans is encoded by the MAGED2 gene.^[1]

This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined.

Further reading

• Lucas S, Brasseur F, Boon T . A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells . Cancer Res. . 59 . 16 . 4100–3 . 1999 . 10463614 .
• Kurt RA, Urba WJ, Schoof DD . Isolation of genes overexpressed in freshly isolated breast cancer specimens . Breast Cancer Res. Treat. . 59 . 1 . 41–8 . 2000 . 10752678 . 10.1023/A:1006315919985 . 22929402 .
• Langnaese K . Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues . Cytogenet. Cell Genet. . 94 . 3–4 . 233–40 . 2002 . 11856887 . 10.1159/000048822 . vanc. Kloos DU . Wehnert M . 3 . Seidel . B. . Wieacker . P. . 44297066 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Bertrand M, Huijbers I, Chomez P, De Backer O . Comparative expression analysis of the MAGED genes during embryogenesis and brain development . Dev. Dyn. . 230 . 2 . 325–34 . 2005 . 15162511 . 10.1002/dvdy.20026 . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Harper R . Identification of a novel MAGE D2 antisense RNA transcript in human tissues . Biochem. Biophys. Res. Commun. . 324 . 1 . 199–204 . 2004 . 15465002 . 10.1016/j.bbrc.2004.09.037 . vanc. Xu C . Di P . 3 . Chen . Yin . Privalsky . Martin . Wu . Reen .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ross MT . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . vanc. Grafham DV . Coffey AJ . 3 . Scherer . Steven . McLay . Kirsten . Muzny . Donna . Platzer . Matthias . Howell . Gareth R. . Burrows . Christine . 2005Natur.434..325R .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . free .
• Papageorgio C . MAGED2: a novel p53-dissociator . Int. J. Oncol. . 31 . 5 . 1205–11 . 2007 . 17912449 . 10.3892/ijo.31.5.1205. vanc. Brachmann R . Zeng J . 3 . Culverhouse . R . Zhang . W . McLeod . H . free.

Notes and References

1. Web site: Entrez Gene: MAGED2 melanoma antigen family D, 2.