MAGEC2 explained
Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.[1] [2]
This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27.[3]
Further reading
- Lucas S, De Plaen E, Boon T . MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. . Int. J. Cancer . 87 . 1 . 55–60 . 2000 . 10861452 . 10.1002/1097-0215(20000701)87:1<55::AID-IJC8>3.0.CO;2-J . 32983052 .
- Sasaki M, Nakahira K, Kawano Y, etal . MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. . Cancer Res. . 61 . 12 . 4809–14 . 2001 . 11406556 .
- Kawano Y, Sasaki M, Nakahira K, etal . Structural characterization and chromosomal localization of the MAGE-E1 gene. . Gene . 277 . 1–2 . 129–37 . 2001 . 11602350 . 10.1016/S0378-1119(01)00698-9 . 2433/149322 . 19474178 . free .
- Wang Y, Han KJ, Pang XW, etal . Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. . J. Immunol. . 169 . 2 . 1102–9 . 2002 . 12097419 . 10.4049/jimmunol.169.2.1102. free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Li B, Qian XP, Pang XW, etal . HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma. . Lab. Invest. . 83 . 8 . 1185–92 . 2003 . 12920247 . 10.1097/01.LAB.0000080605.73839.96 . 2149577 .
- Ma W, Germeau C, Vigneron N, etal . Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. . Int. J. Cancer . 109 . 5 . 698–702 . 2004 . 14999777 . 10.1002/ijc.20038 . 39772412 . free .
- Wang Y, Liang Z, Yuan YH, etal . [Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery] . Zhonghua Yi Xue Za Zhi . 84 . 6 . 464–8 . 2004 . 15061963 .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome. . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .
- Godelaine D, Carrasco J, Brasseur F, etal . A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44. . Cancer Immunol. Immunother. . 56 . 6 . 753–9 . 2007 . 17096150 . 10.1007/s00262-006-0244-5 . 11030963 . 13138922 .
- Yang B, Wu J, Maddodi N, etal . Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. . J. Invest. Dermatol. . 127 . 9 . 2123–8 . 2007 . 17495964 . 10.1038/sj.jid.5700836 . free .
Notes and References
- Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT . CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis . Int J Cancer . 85 . 5 . 726–32 . Mar 2000 . 10699956 . 10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F . 42873107 .
- Web site: Entrez Gene: MAGEC2 melanoma antigen family C, 2.
- Web site: Entrez Gene: MAGEC2 melanoma antigen family C, 2.