MAGEB2 explained

Melanoma-associated antigen B2 is a protein that in humans is encoded by the MAGEB2 gene.^{[1] [2]}

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Dabovic B, Zanaria E, Bardoni B, etal . A family of rapidly evolving genes from the sex reversal critical region in Xp21. . Mamm. Genome . 6 . 9 . 571–80 . 1996 . 8535061 . 10.1007/BF00352360 . 20606673 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• McCurdy DK, Tai LQ, Nguyen J, etal . MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. . Mol. Genet. Metab. . 63 . 1 . 3–13 . 1998 . 9538511 . 10.1006/mgme.1997.2639 .
• Lee JH, Sung BW, Youn HJ, Park JH . Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen. . Mol. Cells . 10 . 6 . 647–53 . 2001 . 11211869 . 10.1007/s10059-000-0647-7 . 25338053 .
• Park JH, Lee SW . Hypertonicity induction of melanoma antigen, a tumor-associated antigen. . Mol. Cells . 13 . 2 . 288–95 . 2003 . 10.1016/S1016-8478(23)15035-7 . 12018852 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ross MT, Grafham DV, Coffey AJ, etal . The DNA sequence of the human X chromosome. . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286 . 2005Natur.434..325R .
• Milutinovic S, D'Alessio AC, Detich N, Szyf M . Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. . Carcinogenesis . 28 . 3 . 560–71 . 2007 . 17012225 . 10.1093/carcin/bgl167 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Lurquin C, De Smet C, Brasseur F, Muscatelli F, Martelange V, De Plaen E, Brasseur R, Monaco AP, Boon T . Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins . Genomics . 46 . 3 . 397–408 . Mar 1998 . 9441743 . 10.1006/geno.1997.5052 .
2. Web site: Entrez Gene: MAGEB2 melanoma antigen family B, 2.