MAGEA9 explained

Melanoma-associated antigen 9 is a protein that in humans is encoded by the MAGEA9 gene.^[1]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[2]

Further reading

• Oehlrich N, Devitt G, Linnebacher M, etal . Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma . Int. J. Cancer . 117 . 2 . 256–64 . 2005 . 15900605 . 10.1002/ijc.21200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lee JH, Sung BW, Youn HJ, Park JH . Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen . Mol. Cells . 10 . 6 . 647–53 . 2001 . 11211869 . 10.1007/s10059-000-0647-7 . 25338053 .
• Serrano A, Lethé B, Delroisse JM, etal . Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries . Int. J. Cancer . 83 . 5 . 664–9 . 1999 . 10521804 . 10.1002/(SICI)1097-0215(19991126)83:5<664::AID-IJC16>3.0.CO;2-V . free .
• Timms KM, Bondeson ML, Ansari-Lari MA, etal . Molecular and phenotypic variation in patients with severe Hunter syndrome . Hum. Mol. Genet. . 6 . 3 . 479–86 . 1997 . 9147653 . 10.1093/hmg/6.3.479 . free .
• De Plaen E, Arden K, Traversari C, etal . Structure, chromosomal localization, and expression of 12 genes of the MAGE family . Immunogenetics . 40 . 5 . 360–9 . 1994 . 7927540 . 10.1007/BF01246677 . 11331427 .

Notes and References

1. Rogner UC, Wilke K, Steck E, Korn B, Poustka A . The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 . Genomics . 29 . 3 . 725–31 . Mar 1996 . 8575766 . 10.1006/geno.1995.9945 .
2. Web site: Entrez Gene: MAGEA9 melanoma antigen family A, 9.