MAGEA2 explained

Melanoma-associated antigen 2 is a protein that in humans is encoded by the MAGEA2 gene.^{[1] [2] [3]}

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Further reading

• Brasseur F, Rimoldi D, Liénard D, etal . Expression of MAGE genes in primary and metastatic cutaneous melanoma. . Int. J. Cancer . 63 . 3 . 375–80 . 1995 . 7591235 . 10.1002/ijc.2910630313 . 38676798 .
• De Plaen E, Arden K, Traversari C, etal . Structure, chromosomal localization, and expression of 12 genes of the MAGE family. . Immunogenetics . 40 . 5 . 360–9 . 1994 . 7927540 . 10.1007/BF01246677 . 11331427 .
• Gaugler B, Van den Eynde B, van der Bruggen P, etal . Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. . J. Exp. Med. . 179 . 3 . 921–30 . 1994 . 8113684 . 10.1084/jem.179.3.921 . 2191409 .
• De Smet C, Lurquin C, van der Bruggen P, etal . Sequence and expression pattern of the human MAGE2 gene. . Immunogenetics . 39 . 2 . 121–9 . 1994 . 8276455 . 10.1007/bf00188615. 13579671 .
• Zakut R, Topalian SL, Kawakami Y, etal . Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines. . Cancer Res. . 53 . 1 . 5–8 . 1993 . 8416750 .
• Mallon AM, Platzer M, Bate R, etal . Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. . Genome Res. . 10 . 6 . 758–75 . 2000 . 10854409 . 10.1101/gr.10.6.758 . 310879 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nagao T, Higashitsuji H, Nonoguchi K, etal . MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity. . J. Biol. Chem. . 278 . 12 . 10668–74 . 2003 . 12525503 . 10.1074/jbc.M206104200 . free . 2433/148472 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Monte M, Simonatto M, Peche LY, etal . MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 30 . 11160–5 . 2006 . 16847267 . 10.1073/pnas.0510834103 . 1544058 . 2006PNAS..10311160M . free .
• Wischnewski F, Friese O, Pantel K, Schwarzenbach H . Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters. . Mol. Cancer Res. . 5 . 7 . 749–59 . 2007 . 17634428 . 10.1158/1541-7786.MCR-06-0364 . free .

Notes and References

1. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T . A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma . Science . 254 . 5038 . 1643–7 . Jan 1992 . 1840703 . 10.1126/science.1840703 .
2. Rogner UC, Wilke K, Steck E, Korn B, Poustka A . The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 . Genomics . 29 . 3 . 725–31 . Mar 1996 . 8575766 . 10.1006/geno.1995.9945 .
3. Web site: Entrez Gene: MAGEA2 melanoma antigen family A, 2.