MAGEA10 explained

MAGEA10 (MAGE family member A10) is a protein-coding gene in humans clustered at chromosomal location Xq28. ^[1]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

Further reading

• Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JM, Orringer MB, Beer DG . Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants . Clin. Cancer Res. . 10 . 17 . 5708–16 . 2004 . 15355897 . 10.1158/1078-0432.CCR-04-0468 .
• Schultz-Thater E, Piscuoglio S, Iezzi G, Le Magnen C, Zajac P, Carafa V, Terracciano L, Tornillo L, Spagnoli GC . MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies . Int. J. Cancer . 129 . 5 . 1137–48 . 2011 . 21710496 . 10.1002/ijc.25777 . free .
• Badovinac Črnjević T, Tanja BČ, Spagnoli G, Giulio S, Juretić A, Antonio J, Jakić-Razumović J, Jasminka JR, Podolski P, Paula P, Šarić N, Nera Š . High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer . Med. Oncol. . 29 . 3 . 1586–91 . 2012 . 22116775 . 10.1007/s12032-011-0120-9 . 22748757 .
• Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W . MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles . Cell. Immunol. . 297 . 1 . 10–8 . 2015 . 26058806 . 10.1016/j.cellimm.2015.05.004 .

Notes and References

1. Web site: Entrez Gene: MAGE family member A10. 2017-06-15.