MAGEA1 explained

Melanoma-associated antigen 1 is a protein that in humans is encoded by the MAGEA1 gene.^[1]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.^[2]

Further reading

• Takahashi K, Shichijo S, Noguchi M, etal . Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis . Cancer Res. . 55 . 16 . 3478–82 . 1995 . 7627949 .
• Celis E, Fikes J, Wentworth P, etal . Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles . Mol. Immunol. . 31 . 18 . 1423–30 . 1995 . 7823968 . 10.1016/0161-5890(94)90158-9 .
• De Plaen E, Arden K, Traversari C, etal . Structure, chromosomal localization, and expression of 12 genes of the MAGE family . Immunogenetics . 40 . 5 . 360–9 . 1994 . 7927540 . 10.1007/BF01246677 . 11331427 .
• Schultz-Thater E, Juretic A, Dellabona P, etal . MAGE-1 gene product is a cytoplasmic protein . Int. J. Cancer . 59 . 3 . 435–9 . 1994 . 7927954 . 10.1002/ijc.2910590324 . 11410139 .
• Ding M, Beck RJ, Keller CJ, Fenton RG . Cloning and analysis of MAGE-1-related genes . Biochem. Biophys. Res. Commun. . 202 . 1 . 549–55 . 1994 . 8037761 . 10.1006/bbrc.1994.1963 .
• Wang MG, Zakut R, Yi H, etal . Localization of the MAGE1 gene encoding a human melanoma antigen to chromosome Xq28 . Cytogenet. Cell Genet. . 67 . 2 . 116–9 . 1994 . 8039421 . 10.1159/000133810 .
• Becker JC, Gillitzer R, Bröcker EB . A member of the melanoma antigen-encoding gene (MAGE) family is expressed in human skin during wound healing . Int. J. Cancer . 58 . 3 . 346–8 . 1994 . 8050815 . 10.1002/ijc.2910580306 . 43714786 .
• Gaugler B, Van den Eynde B, van der Bruggen P, etal . Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes . J. Exp. Med. . 179 . 3 . 921–30 . 1994 . 8113684 . 10.1084/jem.179.3.921 . 2191409 .
• Chen YT, Stockert E, Chen Y, etal . Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies . Proc. Natl. Acad. Sci. U.S.A. . 91 . 3 . 1004–8 . 1994 . 8302824 . 10.1073/pnas.91.3.1004 . 521442 . 1994PNAS...91.1004C . free .
• Rogner UC, Wilke K, Steck E, etal . The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 . Genomics . 29 . 3 . 725–31 . 1996 . 8575766 . 10.1006/geno.1995.9945 .
• Luescher IF, Romero P, Kuznetsov D, etal . HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44 . J. Biol. Chem. . 271 . 21 . 12463–71 . 1996 . 8647853 . 10.1074/jbc.271.21.12463 . free .
• Tanzarella S, Russo V, Lionello I, etal . Identification of a promiscuous T-cell epitope encoded by multiple members of the MAGE family . Cancer Res. . 59 . 11 . 2668–74 . 1999 . 10363990 .
• Mallon AM, Platzer M, Bate R, etal . Comparative genome sequence analysis of the Bpa/Str region in mouse and Man . Genome Res. . 10 . 6 . 758–75 . 2000 . 10854409 . 10.1101/gr.10.6.758 . 310879 .
• Jang SJ, Soria JC, Wang L, etal . Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis . Cancer Res. . 61 . 21 . 7959–63 . 2001 . 11691819 .
• Suyama T, Ohashi H, Nagai H, etal . The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies . Leuk. Res. . 26 . 12 . 1113–8 . 2003 . 12443884 . 10.1016/S0145-2126(02)00048-6 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nagao T, Higashitsuji H, Nonoguchi K, etal . MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity . J. Biol. Chem. . 278 . 12 . 10668–74 . 2003 . 12525503 . 10.1074/jbc.M206104200 . free . 2433/148472 . free .
• Zerbini A, Pilli M, Soliani P, etal . Ex vivo characterization of tumor-derived melanoma antigen encoding gene-specific CD8+cells in patients with hepatocellular carcinoma . J. Hepatol. . 40 . 1 . 102–9 . 2004 . 14672620 . 10.1016/S0168-8278(03)00484-7 .
• Wang LP, Chen HS, Mei MH, etal . [The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients] . Zhonghua Gan Zang Bing Za Zhi . 12 . 3 . 151–5 . 2004 . 15059299 .

Notes and References

1. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T . A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma . Science . 254 . 5038 . 1643–7 . Jan 1992 . 1840703 . 10.1126/science.1840703 .
2. Web site: Entrez Gene: MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E).