MAD2L2 explained

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.^{[1] [2]}

Function

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.^[2]

Interactions

MAD2L2 has been shown to interact with:

• ADAM9,^[3]
• MAD2L1,^[4]
• REV1,^[5] and
• REV3L.^{[4] [5]}

References

Further reading

• Nelson KK, Schlöndorff J, Blobel CP . Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta . Biochem. J. . 343 . 3. 673–680 . 1999 . 10527948 . 1220601 . 10.1042/0264-6021:3430673 . 343 .
• Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R . A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 . J. Biol. Chem. . 275 . 6 . 4391–4397 . 2000 . 10660610 . 10.1074/jbc.275.6.4391 . free .
• Chan SH, Hung FS, Chan DS, Shaw PC . Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B . Eur. J. Biochem. . 268 . 7 . 2107–2112 . 2001 . 11277934 . 10.1046/j.1432-1327.2001.02091.x . free .
• Chen J, Fang G . MAD2B is an inhibitor of the anaphase-promoting complex . Genes Dev. . 15 . 14 . 1765–1770 . 2001 . 11459826 . 312737 . 10.1101/gad.898701 .
• Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M . Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 . J. Biol. Chem. . 276 . 38 . 35644–35651 . 2001 . 11485998 . 10.1074/jbc.M102051200 . free .
• Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG . Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas . Proc. Natl. Acad. Sci. U.S.A. . 98 . 24 . 13808–13813 . 2001 . 11717438 . 61123 . 10.1073/pnas.241304198 . 2001PNAS...9813808W . free .
• Masuda Y, Ohmae M, Masuda K, Kamiya K . Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins . J. Biol. Chem. . 278 . 14 . 12356–12360 . 2003 . 12529368 . 10.1074/jbc.M211765200 . free .
• Ying B, Wold WS . Adenovirus ADP protein (E3–11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B . Virology . 313 . 1 . 224–234 . 2003 . 12951035 . 10.1016/S0042-6822(03)00287-3 .
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–167 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 .
• Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, Ohmori H . Interaction of hREV1 with three human Y-family DNA polymerases . Genes Cells . 9 . 6 . 523–531 . 2004 . 15189446 . 10.1111/j.1356-9597.2004.00747.x . 24470762 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Rimkus C, Friederichs J, Rosenberg R, Holzmann B, Siewert JR, Janssen KP . Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer . Int. J. Cancer . 120 . 1 . 207–211 . 2007 . 17044027 . 10.1002/ijc.22155 . free .
• Zhang L, Yang SH, Sharrocks AD . Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1 . Mol. Cell. Biol. . 27 . 8 . 2861–2869 . 2007 . 17296730 . 1899940 . 10.1128/MCB.02276-06 .
• Pinto M, Soares MJ, Cerveira N, Henrique R, Ribeiro FR, Oliveira J, Jerónimo C, Teixeira MR . Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes . Virchows Arch. . 450 . 4 . 379–385 . 2007 . 17333263 . 10.1007/s00428-007-0386-7 . 36088468 .

Notes and References

1. Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C . Characterization of MAD2B and other mitotic spindle checkpoint genes . Genomics . 58 . 2 . 181–187 . Aug 1999 . 10366450 . 10.1006/geno.1999.5831 . free .
2. Web site: Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast).
3. Nelson KK, Schlöndorff J, Blobel CP . Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta . Biochem. J. . 343 . 3. 673–680 . Nov 1999 . 10527948 . 1220601 . 10.1042/0264-6021:3430673. 343 .
4. Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R . A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 . J. Biol. Chem. . 275 . 6 . 4391–4397 . Feb 2000 . 10660610 . 10.1074/jbc.275.6.4391. free .
5. Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M . Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 . J. Biol. Chem. . 276 . 38 . 35644–35651 . Sep 2001 . 11485998 . 10.1074/jbc.M102051200 . free .