MAD2L1BP explained

MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene.^{[1] [2] [3]}

Function

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Interactions

MAD2L1BP has been shown to interact with TRIP13.^{[4] [5]}

Further reading

• Hoja MR, Wahlestedt C, Höög C . A visual intracellular classification strategy for uncharacterized human proteins . Experimental Cell Research . 259 . 1 . 239–46 . Aug 2000 . 10942595 . 10.1006/excr.2000.4948 .
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y . Protein-protein interaction panel using mouse full-length cDNAs . Genome Research . 11 . 10 . 1758–65 . Oct 2001 . 11591653 . 311163 . 10.1101/gr.180101 .
• Xia G, Luo X, Habu T, Rizo J, Matsumoto T, Yu H . Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint . The EMBO Journal . 23 . 15 . 3133–43 . Aug 2004 . 15257285 . 514937 . 10.1038/sj.emboj.7600322 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH . Mutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma . Experimental & Molecular Medicine . 39 . 4 . 508–13 . Aug 2007 . 17934339 . 10.1038/emm.2007.56 . free .

Notes and References

1. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H . Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Research . 2 . 1 . 37–43 . Jul 1995 . 7788527 . 10.1093/dnares/2.1.37 . free .
2. Habu T, Kim SH, Weinstein J, Matsumoto T . Identification of a MAD2-binding protein, CMT2, and its role in mitosis . The EMBO Journal . 21 . 23 . 6419–28 . Dec 2002 . 12456649 . 136962 . 10.1093/emboj/cdf659 .
3. Web site: Entrez Gene: MAD2L1BP MAD2L1 binding protein.
4. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
5. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .