| Mézilles | |
| Commune Status: | Commune |
| Coordinates: | 47.7017°N 3.1742°W |
| Insee: | 89254 |
| Postal Code: | 89130 |
| Arrondissement: | Auxerre |
| Canton: | Cœur de Puisaye |
| Mayor: | Michel Carré[1] |
| Term: | 2023 - 2026 |
| Elevation Min M: | 191 |
| Elevation Max M: | 286 |
| Area Km2: | 52.42 |
Mézilles (in French pronounced as /mezij/) is a commune in the Yonne department in Bourgogne-Franche-Comté in north-central France, in the historical region of Puisaye.