| Mézières-en-Santerre | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason-Mezieres-en-Santerre.svg |
| Arrondissement: | Montdidier |
| Canton: | Moreuil |
| Insee: | 80545 |
| Postal Code: | 80110 |
| Mayor: | Paul Viollette[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | CC Avre Luce Noye |
| Coordinates: | 49.7867°N 2.5558°W |
| Elevation M: | 98 |
| Elevation Min M: | 63 |
| Elevation Max M: | 105 |
| Area Km2: | 10.71 |
Mézières-en-Santerre (in French pronounced as /mezjɛʁ ɑ̃ sɑ̃tɛʁ/, literally Mézières in Santerre; Mézière-in-Santérre) is a commune in the Somme department in Hauts-de-France in northern France.
The commune is situated on the D28 road, 24km (15miles) southeast of Amiens.