| Official Name: | Mékambo |
| Pushpin Map: | Gabon |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Gabon |
| Subdivision Type: | Country |
| Subdivision Name: |  Gabon |
| Subdivision Name1: | Ogooué-Ivindo Province |
| Subdivision Type2: | Department |
| Unit Pref: | Imperial |
| Population Total: | 4891 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 1.0167°N 69°W |
Mékambo is a small town in north-eastern Gabon on the banks of the Zadié river. It is located in the Ogooué-Ivindo province of Gabon and is the seat of the Zadié Department. It has received international press for recent outbreaks of Ebola hemorrhagic fever in 1994 and 1997.
It is served by Mékambo Airport.
Mékambo has a tropical dry savanna climate (Köppen climate classification As).
Iron ore deposits are found in the vicinity.