Lythranidine Explained

Lythranidine is a piperidine alkaloid that was first isolated from the plant Lythrum anceps.[1] It contains a 17-membered cyclophane ring.

Several laboratory syntheses have been reported.[2] [3] [4] [5]

Notes and References

  1. 10.1039/J39710001651. Lythraceous alkaloids. Part IV. Structure and absolute configuration of lythranine, lythranidine, and lythramine. Journal of the Chemical Society C: Organic. 1651. 1971. Fujita. E. Fuji. K.
  2. 10.1039/P19800001066 . Lythraceous alkaloids. Part 11. Total synthesis of (±)-lythranidine . J. Chem. Soc., Perkin Trans. 1 . 1066–1069 . 1980 . Fuji . Kaoru . Ichikawa . Kohei . Fujita . Eiichi .
  3. 10.1039/P19910000611 . Nitrone cycloaddition: An approach to the cyclophane alkaloid (±)-lythranidine . J. Chem. Soc., Perkin Trans. 1 . 3 . 611–616 . 1991 . Carruthers . William . Coggins . Peter . Weston . John B .
  4. 10.1039/NP9920900491 . Azetidine, pyrrole, pyrrolidine, piperidine, and pyridine alkaloids . Natural Product Reports . 9 . 5 . 491 . 1992 . Pinder . A. R .
  5. 10.1002/anie.201402550 . Total Synthesis of the Biphenyl Alkaloid (−)-Lythranidine . Angewandte Chemie International Edition . 53 . 25 . 6393–6396 . 2014 . Gebauer . Konrad . Fürstner . Alois . 24821137 .

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