Lysosome-associated membrane glycoprotein explained

Lysosome-associated membrane glycoproteins (LAMPs)^{[1] [2] [3] [4]} are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. Structurally, the lamp proteins consist of two internally homologous lysosome-luminal domains separated by a proline-rich hinge region; at the C-terminal extremity there is a transmembrane region (TM) followed by a very short cytoplasmic tail (C). In each of the duplicated domains, there are two conserved disulfide bonds. This structure is schematically represented in the figure below.

+-----+ +-----+ +-----+ +-----+ | | | | | | | | +--------------------------++Hinge++--------------------------++TM++C+

In mammals, there are two closely related types of LAMP: LAMP1 and LAMP2.

CD68 (also called gp110 or macrosialin)^[5] is a heavily glycosylated integral membrane protein whose structure consists of a mucin-like domain followed by a proline-rich hinge; a single LAMP-like domain; a transmembrane region and a short cytoplasmic tail.

CD molecules are leucocyte antigens on cell surfaces. CD antigen nomenclature is updated at Protein Reviews On The Web (https://web.archive.org/web/20080920090434/http://mpr.nci.nih.gov/prow/).

Human proteins containing this domain

• CD68
  • • LAMP1 LAMP2 LAMP3

Notes and References

1. Iwamoto . Tomotada . Sonobe . Toshiaki . Hayashi . Kozaburo . June 2003 . Loop-Mediated Isothermal Amplification for Direct Detection of Mycobacterium tuberculosis Complex, M. avium, and M. intracellulare in Sputum Samples . Journal of Clinical Microbiology . 41 . 6 . 2616–2622 . 10.1128/JCM.41.6.2616-2622.2003 . 156570 . 12791888.
2. Nagamine . K. . Hase . T. . Notomi . T. . June 2002 . Accelerated reaction by loop-mediated isothermal amplification using loop primers . Molecular and Cellular Probes . 16 . 3 . 223–229 . 10.1006/mcpr.2002.0415 . 12144774.
3. Notomi . Tsugunori . Okayama . Hiroto . Masubuchi . Harumi . Yonekawa . Toshihiro . Watanabe . Keiko . Amino . Nobuyuki . Hase . Tetsu . 3 . 2000 . Loop-mediated isothermal amplification of DNA . DNA. Nucleic Acids Res. . 28 . 12 . e63 . 10.1093/nar/28.12.e63 . 102748 . 10871386.
4. Fukuda Minoru . Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking . J. Biol. Chem. . 266 . 32 . 21327–21330 . November 1991 . 10.1016/S0021-9258(18)54636-6 . 1939168 . free .
5. Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL . Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family . J. Biol. Chem. . 268 . 13 . 9661–9666 . 1993 . 10.1016/S0021-9258(18)98400-0 . 8486654 . free .