LPAR3 explained

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene.^[1] LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[2]

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.^[3]

Evolution

Paralogues^[4]

• LPAR1
• LPAR2
• S1PR1
• S1PR3
• S1PR4
• S1PR2
• S1PR5
• CNR1
• GPR3
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• MC3R
• MC1R
• MC2R
• GPR119

See also

• Lysophospholipid receptor

Further reading

• Contos JJ, Ishii I, Chun J . Lysophosphatidic acid receptors. . Mol. Pharmacol. . 58 . 6 . 1188–96 . 2001 . 11093753 . 10.1124/mol.58.6.1188. 6936621 .
• Im DS, Heise CE, Harding MA, etal . Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. . Mol. Pharmacol. . 57 . 4 . 753–9 . 2000 . 10727522 . 10.1124/mol.57.4.753.
• Fitzgerald LR, Dytko GM, Sarau HM, etal . Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid. . Biochem. Biophys. Res. Commun. . 273 . 3 . 805–10 . 2000 . 10891327 . 10.1006/bbrc.2000.2943 .
• Tokumura A, Sinomiya J, Kishimoto S, etal . Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids. . Biochem. J. . 365 . Pt 3 . 617–28 . 2002 . 11982483 . 1222725 . 10.1042/BJ20020348 .
• Hama K, Bandoh K, Kakehi Y, etal . Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. . FEBS Lett. . 523 . 1–3 . 187–92 . 2002 . 12123830 . 10.1016/S0014-5793(02)02976-9 . 44924895 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Cremers B, Flesch M, Kostenis E, etal . Modulation of myocardial contractility by lysophosphatidic acid (LPA). . J. Mol. Cell. Cardiol. . 35 . 1 . 71–80 . 2003 . 12623301 . 10.1016/S0022-2828(02)00279-1 .
• Fujita T, Miyamoto S, Onoyama I, etal . Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. . Cancer Lett. . 192 . 2 . 161–9 . 2003 . 12668280 . 10.1016/S0304-3835(02)00713-9 .
• Jin Y, Knudsen E, Wang L, Maghazachi AA . Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization. . Eur. J. Immunol. . 33 . 8 . 2083–9 . 2003 . 12884281 . 10.1002/eji.200323711 . 41960806 . free .
• Xing Y, Ganji SH, Noh JW, Kamanna VS . Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth. . Am. J. Physiol. Renal Physiol. . 287 . 6 . F1250–7 . 2005 . 15292052 . 10.1152/ajprenal.00342.2003 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .

External links

• Web site: Lysophospholipid Receptors: LPA₃ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-05 . 2016-03-03 . https://web.archive.org/web/20160303193938/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2992 . dead .

Notes and References

1. Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K . Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid . J. Biol. Chem. . 274 . 39 . 27776–85 . September 1999 . 10488122 . 10.1074/jbc.274.39.27776 . free .
2. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J . January 2010 . LPA Receptors: Subtypes and Biological Actions . Annual Review of Pharmacology and Toxicology . 50 . 1 . 157–186 . 10.1146/annurev.pharmtox.010909.105753 . 20055701.
3. Web site: Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3 .
4. Web site: GeneCards®: The Human Gene Database .