LPAR2 explained

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene.^{[1] [2] [3]} LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[4]

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.^[1]

Interactions

LPAR2 has been shown to interact with TRIP6.^[5]

Evolution

Paralogues^{[6] [7]}

• LPAR1
• LPAR3
• S1PR1
• S1PR5
• S1PR4
• S1PR2
• S1PR3
• GPR6
• GPR3
• GPR12
• MC4R
• MC5R
• CNR1
• MC3R
• CNR2
• MC1R
• GPR119

See also

• Lysophospholipid receptor

Further reading

• Spiegel S . Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. . Ann. N. Y. Acad. Sci. . 905 . 1. 54–60 . 2000 . 10818441 . 10.1111/j.1749-6632.2000.tb06537.x . 2000NYASA.905...54S . 9257870 .
• Contos JJ, Ishii I, Chun J . Lysophosphatidic acid receptors. . Mol. Pharmacol. . 58 . 6 . 1188–96 . 2001 . 11093753 . 10.1124/mol.58.6.1188. 6936621 .
• Goetzl EJ, Dolezalova H, Kong Y, etal . Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. . Cancer Res. . 59 . 20 . 5370–5 . 1999 . 10537322 .
• Contos JJ, Chun J . Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. . Genomics . 64 . 2 . 155–69 . 2000 . 10729222 . 10.1006/geno.2000.6122 .
• Bandoh K, Aoki J, Taira A, etal . Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. . FEBS Lett. . 478 . 1–2 . 159–65 . 2000 . 10922489 . 10.1016/S0014-5793(00)01827-5 . 21584151 . free .
• Young KW, Bootman MD, Channing DR, etal . Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. . J. Biol. Chem. . 275 . 49 . 38532–9 . 2001 . 10954727 . 10.1074/jbc.M006631200 . free.
• Zheng Y, Voice JK, Kong Y, Goetzl EJ . Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. . FASEB J. . 14 . 15 . 2387–9 . 2001 . 11024010 . 10.1096/fj.00-0492fje . free . 24778289 .
• Hama K, Bandoh K, Kakehi Y, etal . Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. . FEBS Lett. . 523 . 1–3 . 187–92 . 2002 . 12123830 . 10.1016/S0014-5793(02)02976-9 . 44924895 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Fujita T, Miyamoto S, Onoyama I, etal . Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. . Cancer Lett. . 192 . 2 . 161–9 . 2003 . 12668280 . 10.1016/S0304-3835(02)00713-9 .
• Hu YL, Albanese C, Pestell RG, Jaffe RB . Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells. . J. Natl. Cancer Inst. . 95 . 10 . 733–40 . 2003 . 12759391 . 10.1093/jnci/95.10.733 . free .
• Xu J, Lai YJ, Lin WC, Lin FT . TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. . J. Biol. Chem. . 279 . 11 . 10459–68 . 2004 . 14688263 . 10.1074/jbc.M311891200 . 3904432 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Oh YS, Jo NW, Choi JW, etal . NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. . Mol. Cell. Biol. . 24 . 11 . 5069–79 . 2004 . 15143197 . 416407 . 10.1128/MCB.24.11.5069-5079.2004 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .

External links

• Web site: Lysophospholipid Receptors: LPA₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-05 . 2016-03-03 . https://web.archive.org/web/20160303171034/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2991 . dead .

Notes and References

1. Web site: Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2 .
2. An S, Bleu T, Hallmark OG, Goetzl EJ . Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid . J. Biol. Chem. . 273 . 14 . 7906–10 . April 1998. 9525886 . 10.1074/jbc.273.14.7906. free .
3. An S, Bleu T, Zheng Y, Goetzl EJ . Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization . Mol. Pharmacol. . 54 . 5 . 881–8 . November 1998. 9804623 . 10.1124/mol.54.5.881. 37327084 .
4. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J . January 2010. LPA Receptors: Subtypes and Biological Actions . Annual Review of Pharmacology and Toxicology . 50 . 1 . 157–186 . 10.1146/annurev.pharmtox.010909.105753 . 20055701.
5. Xu . Jun . Lai Yun-Ju . Lin Weei-Chin . Lin Fang-Tsyr . March 2004. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor . J. Biol. Chem. . 279 . 11 . 10459–68 . United States. 0021-9258. 14688263 . 10.1074/jbc.M311891200 . 3904432. free .
6. Web site: GeneCards®: The Human Gene Database .
7. Web site: Ensembl Genome Browser .