Lysobisphosphatidic acid explained

Lysobisphosphatidic acid (LBPA) (also known as bis(monoacylglycero)phosphate (BMP)) is a phospholipid that is found in the membranes of late endosomes and lysosomes of eukaryotic cells.

Phosphatidylglycerol is a precursor and structural isomer of LBPA.^[1] LBPA's stereochemistry is atypical among glycerophospholipids and influences its function within the LE/LY (late endosome/lysosome) system.^{[1] [2]}

LBPA makes up 15–20% of all LE/LY phospholipids and is not found in other subcellular membranes.^[3] LBPA is primarily found within the inner LE/LY membranes where they play a role in their structure and trafficking processes.^{[1] [2]} In particular, an interaction between NPC2 and LBPA is necessary for intracellular cholesterol trafficking.^[1]

See also

• Lysophosphatidic acid
• Niemann-Pick Type C

Notes and References

1. McCauliff . Leslie A . Langan . Annette . Li . Ran . Ilnytska . Olga . Bose . Debosreeta . Waghalter . Miriam . Lai . Kimberly . Kahn . Peter C . Storch . Judith . Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid . eLife . 3 October 2019 . 8 . e50832 . 10.7554/eLife.50832 . 31580258 . 6855803 . 2050-084X . free .
2. Goursot . A. . Mineva . T. . Bissig . C. . Gruenberg . J. . Salahub . D. R. . Structure, Dynamics, and Energetics of Lysobisphosphatidic Acid (LBPA) Isomers . The Journal of Physical Chemistry B . 2 December 2010 . 114 . 47 . 15712–15720 . 10.1021/jp108361d . 21053942 . 9 October 2023 . en . 1520-6106.
3. Ilnytska . Olga . Jeziorek . Maciej . Lai . Kimberly . Altan-Bonnet . Nihal . Dobrowolski . Radek . Storch . Judith . Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . June 2021 . 1866 . 6 . 158916 . 10.1016/j.bbalip.2021.158916 . 33716137 . 8038758 . 1388-1981.