Lysine dehydrogenase explained

lysine dehydrogenase
Ec Number:	1.4.1.15
Cas Number:	68073-29-0
Go Code:	0050069

In enzymology, a lysine dehydrogenase is an enzyme that catalyzes the chemical reaction

L-lysine + NAD⁺

\rightleftharpoons 1,2-didehydropiperidine-2-carboxylate + NH₃ + NADH + H⁺

Thus, the two substrates of this enzyme are L-lysine and NAD⁺, whereas its 4 products are 1,2-didehydropiperidine-2-carboxylate, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-lysine:NAD+ oxidoreductase (deaminating, cyclizing).

References

• Burgi W, Richterich R, Colombo JP . 1966 . L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance . Nature . 211 . 854 - 5 . 4291003 . 10.1038/211854a0 . 5051 .