Lynn Margulis Explained

Lynn Margulis
Birth Name:	Lynn Petra Alexander
Birth Date:	5 March 1938
Birth Place:	Chicago, Illinois, U.S.
Death Place:	Amherst, Massachusetts, U.S.
Field:	Biology
Thesis Title:	An Unusual Pattern of Thymidine Incorporation in Euglena
Thesis Year:	1965
Doctoral Advisor:	Max Alfert
Children:	4

Lynn Margulis (born Lynn Petra Alexander; March 5, 1938 – November 22, 2011) was an American evolutionary biologist, and was the primary modern proponent for the significance of symbiosis in evolution. In particular, Margulis transformed and fundamentally framed current understanding of the evolution of cells with nuclei by proposing it to have been the result of symbiotic mergers of bacteria. Margulis was also the co-developer of the Gaia hypothesis with the British chemist James Lovelock, proposing that the Earth functions as a single self-regulating system, and was the principal defender and promulgator of the five kingdom classification of Robert Whittaker.

Throughout her career, Margulis' work could arouse intense objections,^{[1] [2]} and her formative paper, "On the Origin of Mitosing Cells", appeared in 1967 after being rejected by about fifteen journals. Still a junior faculty member at Boston University at the time, her theory that cell organelles such as mitochondria and chloroplasts were once independent bacteria was largely ignored for another decade, becoming widely accepted only after it was powerfully substantiated through genetic evidence. Margulis was elected a member of the US National Academy of Sciences in 1983. President Bill Clinton presented her the National Medal of Science in 1999. The Linnean Society of London awarded her the Darwin-Wallace Medal in 2008.

Margulis was a strong critic of neo-Darwinism.^[3] Her position sparked lifelong debate with leading neo-Darwinian biologists, including Richard Dawkins,^[4] George C. Williams, and John Maynard Smith.^[1] Margulis' work on symbiosis and her endosymbiotic theory had important predecessors, going back to the mid-19th century – notably Andreas Franz Wilhelm Schimper, Konstantin Mereschkowski, Boris Kozo-Polyansky, and Ivan Wallin – and Margulis not only promoted greater recognition for their contributions, but personally oversaw the first English translation of Kozo-Polyansky's Symbiogenesis: A New Principle of Evolution, which appeared the year before her death. Many of her major works, particularly those intended for a general readership, were collaboratively written with her son Dorion Sagan.

In 2002, Discover magazine recognized Margulis as one of the 50 most important women in science.^[5]

Early life and education

Lynn Petra Alexander^{[6] [7]} was born on March 5, 1938^[8] in Chicago, to a Jewish family.^[9] Her parents were Morris Alexander and Leona Wise Alexander. She was the eldest of four daughters. Her father was an attorney who also ran a company that made road paints. Her mother operated a travel agency.^[10] She entered the Hyde Park Academy High School in 1952,^[11] describing herself as a bad student who frequently had to stand in the corner.^[7]

A precocious child, she was accepted at the University of Chicago Laboratory Schools^[12] at the age of fifteen.^{[13] [14] [15]} In 1957, at age 19, she earned a BA from the University of Chicago in Liberal Arts. She joined the University of Wisconsin to study biology under Hans Ris and Walter Plaut, her supervisor, and graduated in 1960 with an MS in genetics and zoology. (Her first publication, published with Plaut in 1958 in the Journal of Protozoology, was on the genetics of Euglena, flagellates which have features of both animals and plants.)^[16] She then pursued research at the University of California, Berkeley, under the zoologist Max Alfert. Before she could complete her dissertation, she was offered research associateship and then lectureship at Brandeis University in Massachusetts in 1964. It was while working there that she obtained her PhD from the University of California, Berkeley in 1965. Her thesis was An Unusual Pattern of Thymidine Incorporation in Euglena.^[17]

Career

In 1966 she moved to Boston University, where she taught biology for twenty-two years. She was initially an Adjunct Assistant Professor, then was appointed to Assistant Professor in 1967. She was promoted to Associate Professor in 1971, to full Professor in 1977, and to University Professor in 1986. In 1988 she was appointed Distinguished Professor of Botany at the University of Massachusetts at Amherst. She was Distinguished Professor of Biology in 1993. In 1997 she transferred to the Department of Geosciences at UMass Amherst to become Distinguished Professor of Geosciences "with great delight",^[18] the post which she held until her death.^[19]

Endosymbiosis theory

See main article: Symbiogenesis.

In 1966, as a young faculty member at Boston University, Margulis wrote a theoretical paper titled "On the Origin of Mitosing Cells".^[20] The paper, however, was "rejected by about fifteen scientific journals," she recalled.^[21] It was finally accepted by Journal of Theoretical Biology and is considered today a landmark in modern endosymbiotic theory. Weathering constant criticism of her ideas for decades, Margulis was famous for her tenacity in pushing her theory forward, despite the opposition she faced at the time.^[7] The descent of mitochondria from bacteria and of chloroplasts from cyanobacteria was experimentally demonstrated in 1978 by Robert Schwartz and Margaret Dayhoff.^[22] This formed the first experimental evidence for the symbiogenesis theory.^[7] The endosymbiosis theory of organogenesis became widely accepted in the early 1980s, after the genetic material of mitochondria and chloroplasts had been found to be significantly different from that of the symbiont's nuclear DNA.^[23]

In 1995, English evolutionary biologist Richard Dawkins had this to say about Lynn Margulis and her work:

I greatly admire Lynn Margulis's sheer courage and stamina in sticking by the endosymbiosis theory, and carrying it through from being an unorthodoxy to an orthodoxy. I'm referring to the theory that the eukaryotic cell is a symbiotic union of primitive prokaryotic cells. This is one of the great achievements of twentieth-century evolutionary biology, and I greatly admire her for it.^[21]

Symbiosis as evolutionary force

See main article: Symbiosis.

See also: Horizontal gene transfer.

Margulis opposed competition-oriented views of evolution, stressing the importance of symbiotic or cooperative relationships between species.^[24]

She later formulated a theory that proposed symbiotic relationships between organisms of different phyla, or kingdoms, as the driving force of evolution, and explained genetic variation as occurring mainly through transfer of nuclear information between bacterial cells or viruses and eukaryotic cells.^[24] Her organelle genesis ideas are now widely accepted, but the proposal that symbiotic relationships explain most genetic variation is still something of a fringe idea.^[24]

Margulis also held a negative view of certain interpretations of Neo-Darwinism that she felt were excessively focused on competition between organisms, as she believed that history will ultimately judge them as comprising "a minor twentieth-century religious sect within the sprawling religious persuasion of Anglo-Saxon Biology."^[24] She wrote that proponents of the standard theory "wallow in their zoological, capitalistic, competitive, cost-benefit interpretation of Darwin – having mistaken him ... Neo-Darwinism, which insists on [the slow accrual of mutations by gene-level natural selection], is in a complete funk."^[24]

Gaia hypothesis

Margulis initially sought out the advice of James Lovelock for her own research: she explained that, "In the early seventies, I was trying to align bacteria by their metabolic pathways. I noticed that all kinds of bacteria produced gases. Oxygen, hydrogen sulfide, carbon dioxide, nitrogen, ammonia—more than thirty different gases are given off by the bacteria whose evolutionary history I was keen to reconstruct. Why did every scientist I asked believe that atmospheric oxygen was a biological product but the other atmospheric gases—nitrogen, methane, sulfur, and so on—were not? 'Go talk to Lovelock,' at least four different scientists suggested. Lovelock believed that the gases in the atmosphere were biological."^[21]

Margulis met with Lovelock, who explained his Gaia hypothesis to her, and very soon they began an intense collaborative effort on the concept.^[21] One of the earliest significant publications on Gaia was a 1974 paper co-authored by Lovelock and Margulis, which succinctly defined the hypothesis as follows: "The notion of the biosphere as an active adaptive control system able to maintain the Earth in homeostasis we are calling the 'Gaia hypothesis.'"^[25]

Like other early presentations of Lovelock's idea, the Lovelock-Margulis 1974 paper seemed to give living organisms complete agency in creating planetary self-regulation, whereas later, as the idea matured, this planetary-scale self-regulation was recognized as an emergent property of the Earth system, life and its physical environment taken together.^[26] When climatologist Stephen Schneider convened the 1989 American Geophysical Union Chapman Conference around the issue of Gaia, the idea of "strong Gaia" and "weak Gaia" was introduced by James Kirchner, after which Margulis was sometimes associated with the idea of "weak Gaia", incorrectly (her essay "Gaia is a Tough Bitch" dates from 1995 – and it stated her own distinction from Lovelock as she saw it, which was primarily that she did not like the metaphor of Earth as a single organism, because, she said, "No organism eats its own waste").^[21] In her 1998 book Symbiotic Planet, Margulis explored the relationship between Gaia and her work on symbiosis.^[27]

Five kingdoms of life

In 1969, life on earth was classified into five kingdoms, as introduced by Robert Whittaker.^[28] Margulis became the most important supporter, as well as critic^[29] – while supporting parts, she was the first to recognize the limitations of Whittaker's classification of microbes.^[30] But later discoveries of new organisms, such as archaea, and emergence of molecular taxonomy challenged the concept.^[31] By the mid-2000s, most scientists began to agree that there are more than five kingdoms.^{[32] [33]} Margulis became the most important defender of the five kingdom classification. She rejected the three-domain system introduced by Carl Woese in 1990, which gained wide acceptance. She introduced a modified classification by which all life forms, including the newly discovered, could be integrated into the classical five kingdoms. According to Margulis, the main problem, archaea, falls under the kingdom Prokaryotae alongside bacteria (in contrast to the three-domain system, which treats archaea as a higher taxon than kingdom, or the six-kingdom system, which holds that it is a separate kingdom).^[31] Margulis' concept is given in detail in her book Five Kingdoms, written with Karlene V. Schwartz.^[34] It has been suggested that it is mainly because of Margulis that the five-kingdom system survives.^[18]

Metamorphosis theory

In 2009, via a then-standard publication-process known as "communicated submission" (which bypassed traditional peer review), she was instrumental in getting the Proceedings of the National Academy of Sciences (PNAS) to publish a paper by Donald I. Williamson rejecting "the Darwinian assumption that larvae and their adults evolved from a single common ancestor."^{[35] [36]} Williamson's paper provoked immediate response from the scientific community, including a countering paper in PNAS.^[35] Conrad Labandeira of the Smithsonian National Museum of Natural History said, "If I was reviewing [Williamson's paper] I would probably opt to reject it," he says, "but I'm not saying it's a bad thing that this is published. What it may do is broaden the discussion on how metamorphosis works and [...] [on] the origin of these very radical life cycles." But Duke University insect developmental biologist Fred Nijhout said that the paper was better suited for the "National Enquirer than the National Academy."^[37] In September it was announced that PNAS would eliminate communicated submissions in July 2010. PNAS stated that the decision had nothing to do with the Williamson controversy.

AIDS/HIV theory

In 2009 Margulis and seven others authored a position paper concerning research on the viability of round body forms of some spirochetes, "Syphilis, Lyme disease, & AIDS: Resurgence of 'the great imitator'?"^[38] which states that, "Detailed research that correlates life histories of symbiotic spirochetes to changes in the immune system of associated vertebrates is sorely needed", and urging the "reinvestigation of the natural history of mammalian, tick-borne, and venereal transmission of spirochetes in relation to impairment of the human immune system". The paper went on to suggest "that the possible direct causal involvement of spirochetes and their round bodies to symptoms of immune deficiency be carefully and vigorously investigated".^[38]

In a Discover Magazine interview, Margulis explained her reason for interest in the topic of the 2009 "AIDS" paper: "I'm interested in spirochetes only because of our ancestry. I'm not interested in the diseases", and stated that she had called them "symbionts" because both the spirochete which causes syphilis (Treponema) and the spirochete which causes Lyme disease (Borrelia) only retain about 20% of the genes they would need to live freely, outside of their human hosts.^[3]

However, in the Discover Magazine interview Margulis said that "the set of symptoms, or syndrome, presented by syphilitics overlaps completely with another syndrome: AIDS", and also noted that Kary Mullis said that "he went looking for a reference substantiating that HIV causes AIDS and discovered, 'There is no such document' ".^[3]

This provoked a widespread supposition that Margulis had been an "AIDS denialist". Jerry Coyne reacted on his Why Evolution is True blog against his interpretation that Margulis believed "that AIDS is really syphilis, not viral in origin at all."^[39] Seth Kalichman, a social psychologist who studies behavioral and social aspects of AIDS, cited her [Margulis] 2009 paper as an example of AIDS denialism "flourishing",^[40] and asserted that her [Margulis] "endorsement of HIV/AIDS denialism defies understanding".^[41]

Reception

Historian Jan Sapp has said that "Lynn Margulis's name is as synonymous with symbiosis as Charles Darwin's is with evolution." She has been called "science's unruly earth mother",^[42] a "vindicated heretic",^[43] or a scientific "rebel",^[44] It has been suggested that initial rejection of Margulis' work on the endosymbiotic theory, and the controversial nature of it as well as Gaia theory, made her identify throughout her career with scientific mavericks, outsiders, and unaccepted theories generally.^[1]

In the last decade of her life, while key components of her life's work began to be understood as fundamental to a modern scientific viewpoint – the widespread adoption of Earth System Science and the incorporation of key parts of endosymbiotic theory into biology curricula worldwide – Margulis if anything became more embroiled in controversy, not less. Journalist John Wilson explained this by saying that Lynn Margulis "defined herself by oppositional science,"^[45] and in the commemorative collection of essays Lynn Margulis: The Life and Legacy of a Scientific Rebel, commentators again and again depict her as a modern embodiment of the "scientific rebel",^[1] akin to Freeman Dyson's 1995 essay The Scientist as Rebel, a tradition Dyson saw embodied in Benjamin Franklin, and which Dyson believed to be essential to good science.^[46]

Awards and recognitions

• 1975, Elected Fellow of the American Association for the Advancement of Science.^[17]
• 1978, Guggenheim Fellowship.^[19]
• 1983, Elected to the National Academy of Sciences.^[47]
• 1985, Guest Hagey Lecturer, University of Waterloo.^[48]
• 1986, Miescher-Ishida Prize.^[19]
• 1989, conferred the Commandeur de l'Ordre des Palmes Académiques de France.^[17]
• 1992, recipient of Chancellor's Medal for Distinguished Faculty of the University of Massachusetts at Amherst.^[18]
• 1995, elected Fellow of the World Academy of Art and Science.^{[49] [50]}
• 1997, elected to the Russian Academy of Natural Sciences.^{[7] [49]}
• 1998, papers permanently archived in the Library of Congress, Washington, D.C.^[51]
• 1998, recipient of the Distinguished Service Award of the American Institute of Biological Sciences.^[18]
• 1998, elected Fellow of the American Academy of Arts and Sciences.^[52]
• 1999, recipient of the William Procter Prize for Scientific Achievement.^[53]
• 1999, recipient of the National Medal of Science, awarded by President William J. Clinton.^{[54] [55] [56]}
• 2001, Golden Plate Award of the American Academy of Achievement^[57]
• 2002–05, Alexander von Humboldt Prize.^[58]
• 2005, elected President of Sigma Xi, The Scientific Research Society.^[49]
• 2006, Founded Sciencewriters Books with her son Dorion.^[59]
• 2008, one of thirteen recipients in 2008 of the Darwin-Wallace Medal, heretofore bestowed every 50 years, by the Linnean Society of London.^[60]
• 2010, inductee into the Leonardo da Vinci Society of Thinking^[61] at the University of Advancing Technology in Tempe, Arizona.
• 2010, NASA Public Service Award for Astrobiology.^[19]
• 2012, Lynn Margulis Symposium: Celebrating a Life in Science, University of Massachusetts, Amherst, March 23–25, 2012.^[62]
• 2017, the Journal of Theoretical Biology 434, 1–114 commemorated the 50th anniversary of "The origin of mitosing cells" with a special issue
• Honorary doctorate from 15 universities.^[49]

Personal life

Margulis married astronomer Carl Sagan in 1957 soon after she got her bachelor's degree. Sagan was then a graduate student in physics at the University of Chicago. Their marriage ended in 1964, just before she completed her PhD. They had two sons, Dorion Sagan, who later became a popular science writer and her collaborator, and Jeremy Sagan, software developer and founder of Sagan Technology.

In 1967 she married Thomas N. Margulis, a crystallographer. They had a son named Zachary Margulis-Ohnuma, a New York City criminal defense lawyer, and a daughter Jennifer Margulis, teacher and author.^{[63] [64]} They divorced in 1980.

She commented, "I quit my job as a wife twice," and, "it's not humanly possible to be a good wife, a good mother, and a first-class scientist. No one can do it — something has to go."^[64]

In the 2000s she had a relationship with fellow biologist Ricardo Guerrero.^[11]

Margulis argued that the September 11 attacks were a "false-flag operation, which has been used to justify the wars in Afghanistan and Iraq as well as unprecedented assaults on [...] civil liberties." She wrote that there was "overwhelming evidence that the three buildings [of the World Trade Center] collapsed by controlled demolition."^[1]

She was a religious agnostic,^[11] and a staunch evolutionist, but rejected the modern evolutionary synthesis,^[3] and said: "I remember waking up one day with an epiphanous revelation: I am not a neo-Darwinist! I recalled an earlier experience, when I realized that I wasn't a humanistic Jew. Although I greatly admire Darwin's contributions and agree with most of his theoretical analysis and I am a Darwinist, I am not a neo-Darwinist."^[21] She argued that "Natural selection eliminates and maybe maintains, but it doesn't create", and maintained that symbiosis was the major driver of evolutionary change.^[3]

Margulis died on November 22, 2011, at home in Amherst, Massachusetts, five days after suffering a hemorrhagic stroke.^{[8] [6] [7] [64] [65]} As her wish, she was cremated and her ashes were scattered in her favorite research areas, near her home.^[66]

Works

Books

• Margulis, Lynn (1970). Origin of Eukaryotic Cells, Yale University Press,
• Margulis, Lynn (1982). Early Life, Science Books International,
• Margulis, Lynn, and Dorion Sagan (1986). Origins of Sex : Three Billion Years of Genetic Recombination, Yale University Press,
• Margulis, Lynn, and Dorion Sagan (1987). Microcosmos: Four Billion Years of Evolution from Our Microbial Ancestors, HarperCollins,
• Margulis, Lynn, and Dorion Sagan (1991). Mystery Dance: On the Evolution of Human Sexuality, Summit Books,
• Margulis, Lynn, ed. (1991). Symbiosis as a Source of Evolutionary Innovation: Speciation and Morphogenesis, The MIT Press,
• Book: Margulis . Lynn . Evolution of Life . Osawa . Syozo . Honzo . Tasuku . 1991 . Springer . Japan . 978-4-431-68304-9 . 305–324 . 10.1007/978-4-431-68302-5_19 . Symbiosis in Evolution: Origins of Cell Motility.
• Margulis, Lynn (1992). Symbiosis in Cell Evolution: Microbial Communities in the Archean and Proterozoic Eons, W.H. Freeman,
• Sagan, Dorion, and Margulis, Lynn (1993). The Garden of Microbial Delights: A Practical Guide to the Subvisible World, Kendall/Hunt,
• Margulis, Lynn, Dorion Sagan and Niles Eldredge (1995) What Is Life?, Simon and Schuster,
• Margulis, Lynn, and Dorion Sagan (1997). Slanted Truths: Essays on Gaia, Symbiosis, and Evolution, Copernicus Books,
• Margulis, Lynn, and Dorion Sagan (1997). What Is Sex?, Simon and Schuster,
• Margulis, Lynn, and Karlene V. Schwartz (1997). Five Kingdoms: An Illustrated Guide to the Phyla of Life on Earth, W.H. Freeman & Company,
• Margulis, Lynn (1998). Symbiotic Planet : A New Look at Evolution, Basic Books,
• Margulis, Lynn, et al. (2002). The Ice Chronicles: The Quest to Understand Global Climate Change, University of New Hampshire,
• Margulis, Lynn, and Dorion Sagan (2002). Acquiring Genomes: A Theory of the Origins of Species, Perseus Books Group,
• Margulis, Lynn (2007). Luminous Fish: Tales of Science and Love, Sciencewriters Books,
• Margulis, Lynn, and Eduardo Punset, eds. (2007). Mind, Life and Universe: Conversations with Great Scientists of Our Time, Sciencewriters Books,
• Margulis, Lynn, and Dorion Sagan (2007). Dazzle Gradually: Reflections on the Nature of Nature, Sciencewriters Books,
• Book: Margulis . Lynn . Horizontal Gene Transfer . Genome Acquisition in Horizontal Gene Transfer: Symbiogenesis and Macromolecular Sequence Analysis . 2009 . 532 . 181–191 . 10.1007/978-1-60327-853-9_10 . 19271185 . 978-1-60327-852-2 . Humana Press . Gogarten, Maria Boekels . Gogarten, Johann Peter . Gogarten, Johann Peter . Olendzenski, Lorraine C. . Methods in Molecular Biology .

Journals

• Margulis (Sagan) . L . On the Origin of Mitosing Cells . . 1967 . 14 . 3 . 225–274 . 11541392 . 10.1016/0022-5193(67)90079-3. 1967JThBi..14..225S .
• Margulis . L . Genetic and evolutionary consequences of symbiosis . . 1976 . 39 . 2 . 277–349 . 816668 . 10.1016/0014-4894(76)90127-2.
• Margulis . L . Undulipodia, flagella and cilia . Biosystems . 1980 . 12 . 1–2 . 105–108 . 7378551 . 10.1016/0303-2647(80)90041-6. 1980BiSys..12..105M .
• Margulis . L . Bermudes . D . Symbiosis as a mechanism of evolution: status of cell symbiosis theory . Symbiosis . 1985 . 1 . 101–124 . 11543608.
• Sagan . D . Margulis . L . Gaia and the evolution of machines. . . 1987 . 55 . 15–21 . 11542102.
• Bermudes . D . Margulis . L . Tzertzinis . G . Prokaryotic origin of undulipodia. Application of the panda principle to the centriole enigma . . 1987 . 503 . 1 . 187–197 . 10.1111/j.1749-6632.1987.tb40608.x . 3304075. 1987NYASA.503..187B . 39709909 .
• Lazcano . A . Guerrero . R . Margulis . L . Oró . J . The evolutionary transition from RNA to DNA in early cells. . . 1988 . 27 . 4 . 283–290 . 2464698 . 10.1007/bf02101189. 1988JMolE..27..283L . 21008416 .
• Margulis . L . Words as battle cries—symbiogenesis and the new field of endocytobiology . . 1990 . 40 . 9 . 673–677 . 11541293 . 10.2307/1311435. 1311435 .
• Margulis . L . Archaeal-eubacterial mergers in the origin of Eukarya: phylogenetic classification of life. . Proceedings of the National Academy of Sciences of the United States of America . 1996 . 93 . 3 . 1071–1076 . 8577716 . 40032 . 10.1073/pnas.93.3.1071. 1996PNAS...93.1071M . free .
• Chapman . MJ . Margulis . L . Morphogenesis by symbiogenesis . International Microbiology . 1998 . 1 . 4 . 319–26 . 10943381.
• Margulis . L. . Dolan . M. F. . Guerrero . R. . The chimeric eukaryote: Origin of the nucleus from the karyomastigont in amitochondriate protists . Proceedings of the National Academy of Sciences . 2000 . 97 . 13 . 6954–6959 . 10.1073/pnas.97.13.6954 . 10860956 . 34369. 2000PNAS...97.6954M . free .
• Wier . A. . Dolan . M. . Grimaldi . D. . Guerrero . R. . Wagensberg . J. . Margulis . L. . Spirochete and protist symbionts of a termite (Mastotermes electrodominicus) in Miocene amber . Proceedings of the National Academy of Sciences . 2002 . 99 . 3 . 1410–1413 . 10.1073/pnas.022643899 . 11818534 . 122204. 2002PNAS...99.1410W . free .
• Dolan . Michael F. . Melnitsky . Hannah . Margulis . Lynn . Kolnicki . Robin . Motility proteins and the origin of the nucleus . . 2002 . 268 . 3 . 290–301 . 10.1002/ar.10161 . 12382325. 7405778 . free .
• Margulis . L . Hans Ris (1914–2004). Genophore, chromosomes and the bacterial origin of chloroplasts . International Microbiology . 2005 . 8 . 2 . 145–8 . 16052465.
• Margulis . L. . Chapman . M. . Guerrero . R. . Hall . J. . The last eukaryotic common ancestor (LECA): Acquisition of cytoskeletal motility from aerotolerant spirochetes in the Proterozoic Eon . Proceedings of the National Academy of Sciences . 2006 . 103 . 35 . 13080–13085 . 10.1073/pnas.0604985103 . 16938841 . 1559756. 2006PNAS..10313080M . free .
• Dolan . MF . Margulis . L . Advances in biology reveal truth about prokaryotes . Nature . 2007 . 445 . 7123 . 21 . 10.1038/445021b . 17203039. 2007Natur.445...21D . 4426413 . free .
• Margulis . Lynn . Chapman . Michael . Dolan . Michael F. . Semes for analysis of evolution: de Duve's peroxisomes and Meyer's hydrogenases in the sulphurous Proterozoic eon . . 2007 . 8 . 10 . 1 . 10.1038/nrg2071-c1 . 17923858. 33808568 . free .
• Brorson . O. . Brorson . S.-H. . Scythes . J. . MacAllister . J. . Wier . A. . Margulis . L. . Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic Tigecycline . . 2009 . 106 . 44 . 18656–18661 . 10.1073/pnas.0908236106 . 19843691 . 2774030. 2009PNAS..10618656B . free .
• Wier . AM . Sacchi . L . Dolan . MF . Bandi . C . Macallister . J . Margulis . L . Spirochete attachment ultrastructure: Implications for the origin and evolution of cilia . . 2010 . 218 . 1 . 25–35 . 20203251. 10.1086/BBLv218n1p25 . 21634272 .
• Guerrero . R . Margulis . L . Berlanga . M . Bandi . C . Macallister . J . Margulis . L . Symbiogenesis: the holobiont as a unit of evolution . . 2013 . 16 . 3 . 133–143 . 10.2436/20.1501.01.188 . 24568029.

External links

• Web site: Lynn Margulis . UMass . Biology .
• Web site: Endosymbiotic Theory . Worksheet . January 14, 2002 . N100 . . March 12, 2005 . https://web.archive.org/web/20070908232900/http://www.biology.iupui.edu/biocourses/N100/2k2endosymb.html . September 8, 2007 . dead . none.
• Rutgers Interview . 2004 . Jay . Tischfield . video . none.
  • • • • • • • documentary film . Symbiotic Earth: How Lynn Margulis rocked the boat and started a scientific revolution . A film by John Feldman; script, John Feldman; producer, Susan Davies; a Hummingbird Films production . Oley, PA . Bullfrog Films . 2018 . 1032829183.
• Web site: Acquiring Genomes . Lynn Margulis . March 10, 2005 . San Jose Science, Technology and Society: 2005–2006 Linus Pauling Memorial Lectures . Institute for Science, Engineering, and Public Policy . March 12, 2005 . https://web.archive.org/web/20070928083546/http://www.isepp.org/Pages/San%20Jose%2004-05/MargulisSaganSJ.html . September 28, 2007 . dead .

Notes and References

1. Book: Lynn Margulis: The Life and Legacy of a Scientific Rebel . Chelsea Green . 2012 . 978-1603584470 . Sagan . Dorion . White River Junction.
2. Web site: 13 December 2011. Lynn Margulis. https://ghostarchive.org/archive/20220112/https://www.telegraph.co.uk/news/obituaries/science-obituaries/8954456/Lynn-Margulis.html . 2022-01-12 . live. subscription. 2021-03-09. The Telegraph. en-GB.
3. Teresi . Dick . Dick Teresi . Discover Interview . 17 June 2011 . Lynn Margulis says she's not controversial, she's right . . April 2011 . 22 June 2023. [Broken link]
4. Gilbert . Scott F. . Scott F. Gilbert . Sapp . Jan . Jan Sapp . Tauber . Alfred I. . Alfred I. Tauber . A Symbiotic View of Life: We have never been individuals . . 2012 . 87 . 4 . 325–341 . 10.1086/668166 . 23397797 . 14279096 .
5. Svitil. Kathy. The 50 Most Important Women in Science . 1 May 2019 . . 13 November 2002.
6. News: Weber . Bruce . Lynn Margulis, evolution theorist, dies at 73 . 25 July 2014 . . 24 November 2011.
7. Lake . James A. . James A. Lake . Lynn Margulis (1938–2011) . Nature . 2011 . 480 . 7378 . 458 . 10.1038/480458a . 22193092 . 2011Natur.480..458L. 205069081 . free .
8. Schaechter . M . Lynn Margulis (1938–2011) . Science . 2012 . 335 . 6066 . 302 . 10.1126/science.1218027 . 22267805 . 2012Sci...335..302S. 36800637 .
9. Web site: Goldman . Jason . Ad Memoriam: Lynn Margulis (5.03.1938 - 22.11.2011) . Jason G. Goldman . September 14, 2015.
10. Book: Oakes . Elizabeth H. . Encyclopedia of World Scientists . 2007 . Facts on File . New York . 978-1-4381-1882-6 . 484 . Revised .
11. Web site: Lynn Margulis . NNDB . Soylent Communications . December 18, 2014.
12. di Properzio . James . Lynn Margulis: Full speed ahead . University of Chicago Magazine . February 1, 2004 . July 25, 2014 . dead . https://web.archive.org/web/20140723105346/http://www.mindfully.org/Heritage/2004/Lynn-Margulis-Gaia1feb04.htm . July 23, 2014.
13. Web site: Scoville . Heather . Lynn Margulis . About.com . December 18, 2014 . December 18, 2014 . https://web.archive.org/web/20141218165240/http://evolution.about.com/od/scientists/p/Lynn-Margulis.htm . dead .
14. Encyclopedia: Lynn Margulis . Encyclopedia of World Biography . December 18, 2014 . 2004.
15. BBC Radio 4 . A Life With ... . Series 5 . interview . A life with Microbes . July 16, 2009.
16. Book: Archibald . John . One Plus One Equals One: Symbiosis and the evolution of complex life . 2014 . Oxford University Press . Oxford . 978-0-19-966059-9 . 50 .
17. Book: Una revolución en la evolución: Escritos seleccionados. Universitat de Valencia . 2002 . 978-8-437-05494-0 . Valencia . 45–48 . es . Margulis . Lynn.
18. Book: Yount . Lisa . A to Z of biologists . 2003 . Facts on File . New York, NY . 978-1-4381-0917-6 . 198 .
19. Encyclopedia: Haskett . Dorothy Regan . Lynn Petra Alexander Sagan Margulis (1938–2011) . The Embryo Project Encyclopedia . Arizona Board of Regents, Arizona State University . December 18, 2014.
20. Sagan . Lynn . On the origin of mitosing cells . Journal of Theoretical Biology . 1967 . 14 . 3 . 225–274 . 10.1016/0022-5193(67)90079-3 . 11541392. 1967JThBi..14..225S .
21. Margulis, Lynn, Gaia Is a Tough Bitch . Chapter 7 in The Third Culture: Beyond the Scientific Revolution by John Brockman (Simon & Schuster, 1995)
22. Schwartz . R. . Dayhoff . M. . Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts . Science . 1978 . 199 . 4327 . 395–403 . 10.1126/science.202030 . 202030 . 1978Sci...199..395S.
23. Encyclopedia: Nicholas W. . Gillham . Chloroplasts and Mitochondria . Encyclopedia of Genetics . Eric C.R. . Reeve . January 14, 2014 . Routledge . 978-1-134-26350-9 . 721–735.
24. Mann . C . Lynn Margulis: Science's unruly Earth mother . Science . 1991 . 252 . 5004 . 378–381 . 10.1126/science.252.5004.378 . 1991Sci...252..378M . 17740930.
25. Lovelock . J.E. . Margulis . L. . 1974 . Atmospheric homeostasis by and for the biosphere: the gaia hypothesis . Tellus A . 26 . 1–2 . 2–10 . 10.3402/tellusa.v26i1-2.9731 . free . 129803613 . en . 1974Tell...26....2L .
26. Book: Lovelock. James. The Ages of Gaia: A Biography of Our Living Earth. 1988. W.W.Norton & Co. New York.
27. Book: Margulis . Lynn . Symbiotic Planet . 1998 . Basic Books . New York, NY.
28. Whittaker . R.H. . January 1969 . New concepts of kingdoms or organisms. Evolutionary relations are better represented by new classifications than by the traditional two kingdoms. Science. 163 . 3863. 150–60 . 5762760 . 10.1126/science.163.3863.150. 1969Sci...163..150W . 10.1.1.403.5430 .
29. Book: Margulis. Lynn . Five-Kingdom Classification and the Origin and Evolution of Cells . Evolutionary Biology . BMC Evolutionary Biology . 1974. 7. 45–78. 10.1007/978-1-4615-6944-2_2. 17376230. 1847511. 978-1-4615-6946-6.
30. Margulis. Lynn. Whittaker's Five Kingdoms of Organisms: Minor Revisions Suggested by Considerations of the Origin of Mitosis. Evolution. 1971. 25. 1. 242–245. 2406516. 10.2307/2406516. 28562945.
31. Hagen. Joel B.. Five Kingdoms, More or Less: Robert Whittaker and the Broad Classification of Organisms. BioScience. 2012. 62. 1. 67–74. 10.1525/bio.2012.62.1.11. 86253586. free.
32. Simpson. Alastair G.B.. Roger . Andrew J.. 2004 . The real 'kingdoms' of eukaryotes . Current Biology . 14 . 17. R693–6. amp . 15341755 . 10.1016/j.cub.2004.08.038. 207051421. free. 2004CBio...14.R693S .
33. Adl. SM. Simpson. AG. Farmer. MA. Andersen. RA. Anderson. OR. Barta. JR. Bowser. SS. Brugerolle. G. The new higher level classification of eukaryotes with emphasis on the taxonomy of protists.. The Journal of Eukaryotic Microbiology. 2005. 52. 5. 399–451. 10.1111/j.1550-7408.2005.00053.x. 16248873. 8060916. etal. free.
34. Web site: Tao. Amy. Lynn Margulis. Encyclopædia Britannica. December 18, 2014. October 22, 2013.
35. Williamson. D. I.. Caterpillars evolved from onychophorans by hybridogenesis. Proceedings of the National Academy of Sciences. 2009. 106. 47. 19901–19905. 10.1073/pnas.0908357106. 19717430. 2785264. 2009PNAS..10619901W. free.
36. http://blogs.scientificamerican.com/observations/2009/10/29/controversial-caterpillar-evolution-study-formally-rebutted/ Controversial caterpillar-evolution study formally rebutted
37. Borrell . Brendan . National Academy as National Enquirer ? PNAS Publishes Theory That Caterpillars Originated from Interspecies Sex . Scientific American . November 23, 2011.
38. Syphilis, Lyme disease & AIDS: Resurgence of "the great imitator"? . Symbiosis . 47 . 1 . 2009 . 51–58. 10.1007/BF03179970 . Margulis . Lynn . Maniotis . Andrew . MacAllister . James . Scythes . John . Brorson . Oystein . Hall . John . Krumbein . Wolfgang E. . Chapman . Michael J. . 25177964 .
39. Web site: Jerry Coyne . Why Evolution is True . Lynn Margulis disses evolution in Discover Magazine – Embarrasses both herself and the field. April 12, 2011 .
40. Kalichman . S. C. . Eaton . L. . Cherry . C. . 10.1007/s10865-010-9275-7 . "There is no Proof that HIV Causes AIDS": AIDS denialism beliefs among people living with HIV/AIDS . Journal of Behavioral Medicine . 33 . 6 . 432–440 . 2010 . 20571892 . 3015095.
41. Book: Seth C. Kalichman . Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy . Seth Kalichman . January 16, 2009 . Springer Science & Business Media . 978-0-387-79476-1 . 181–82.
42. Mann . C . Lynn Margulis: Science's unruly Earth mother . Science . 1991 . 252 . 5004 . 378–381 . 10.1126/science.252.5004.378 . 1991Sci...252..378M . 17740930.
43. Book: Barlow . Connie . From Gaia to Selfish Genes: Selected writings in the life sciences . 1992 . MIT Press . Cambridge, MA . 978-0-262-52178-9 . 47 . 1st MIT Press paperback .
44. News: Fiveash . Kelly . 'Rebel' biologist and neo-Darwinian skeptic Lynn Margulis dies . 19 December 2014 . . 24 November 2011.
45. Wilson. John. Christopher Hitchens, Lynn Margulis, George Whitman and Jerry Robinson. The Last Word with John Wilson. July 25, 2015. BBC Radio 4. December 16, 2011.
46. Book: Dyson. Freeman. The Scientist as Rebel. 2006. New York Review of Books. New York. 978-1-59017-216-2.
47. Web site: Lynn Margulis . November 13, 2023 . www.nasonline.org.
48. Web site: Guest Lecturers . June 19, 2009 . https://web.archive.org/web/20111007201542/http://www.fauw.uwaterloo.ca/Pages/Archives/PreviousHageyLectures.htm . October 7, 2011 . dead .
49. Web site: Margulis. Lynn. Curriculum Vitae. December 19, 2014. December 19, 2014. https://web.archive.org/web/20141219142701/http://www.bib.ub.edu/fileadmin/bibs/biologia/Lynn_margulis/curriculum_margulis.pdf. dead.
50. Web site: Lynn Margulis | World Academy of Art & Science . Worldacademy.org . November 18, 2011 . November 23, 2011 . dead . https://web.archive.org/web/20120330012531/http://www.worldacademy.org/content/lynn-margulis . March 30, 2012 .
51. Web site: Lynn Margulis . November 13, 2023 . www.geo.umass.edu.
52. Biologist Lynn Margulis of UMass Amherst Elected Fellow of American Academy of Arts & Sciences. May 5, 1998. University of Massachusetts Amherst. Amherst, Massachusetts. January 29, 2016. August 24, 2016. https://web.archive.org/web/20160824113031/http://www.umass.edu/newsoffice/article/biologist-lynn-margulis-umass-amherst-elected-fellow-american-academy-arts-sciences. dead.
53. Web site: Lynn Margulis . November 13, 2023 . www.sigmaxi.org.
54. Web site: Lynn Margulis . November 13, 2023 . National Science and Technology Medals Foundation . en-US.
55. Web site: The President's National Medal of Science: Recipient Details NSF - National Science Foundation . November 13, 2023 . www.nsf.gov.
56. Web site: President Clinton Announces 1999 National Medal of Science and National Medal of Technology Awardees . November 13, 2023 . clintonwhitehouse4.archives.gov.
57. Web site: Golden Plate Awardees of the American Academy of Achievement . www.achievement.org. American Academy of Achievement.
58. Web site: Barcelona . Universitat Autònoma de . Lynn Margulis, a microbiologist at the U.S. considered one of the leading figures in the evolution theory . November 13, 2023 . UABDivulga Barcelona Research & Innovation . en.
59. Book: Launches Sciencewriters Imprint . Chelsea Green . July 22, 2006 . November 23, 2011.
60. Web site: December 28, 2016 . Lynn Margulis . November 13, 2023 . The Montgomery Fellows . en.
61. Web site: Lynn Margulis. University of Advancing Technology. July 25, 2014. dead. https://web.archive.org/web/20140728172240/http://www.davincithinking.org/margulis/. July 28, 2014.
62. Web site: Memorials . November 13, 2023 . www.geo.umass.edu.
63. Web site: Lynn Margulis . . July 25, 2014.
64. News: Weil . Martin . Lynn Margulis, leading evolutionary biologist, dies at 73 . December 19, 2014 . . November 26, 2011.
65. News: Rose . Steven . Lynn Margulis obituary . July 25, 2014 . The Guardian . UK . December 11, 2011.
66. Web site: Faulkner . Sean . Condolences . geo.umass.edu . December 20, 2014.