LSP1 explained

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.^{[1] [2]}

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Jongstra-Bilen J, Young AJ, Chong R, Jongstra J . Human and mouse LSP1 genes code for highly conserved phosphoproteins . J. Immunol. . 144 . 3 . 1104–10 . 1990 . 10.4049/jimmunol.144.3.1104 . 2295815 .
• Klein DP . Lymphocyte-specific Ca2+-binding protein LSP1 is associated with the cytoplasmic face of the plasma membrane . Mol. Cell. Biol. . 9 . 7 . 3043–8 . 1989 . 2674678 . 10.1128/mcb.9.7.3043. 362773 . Jongstra-Bilen J . Ogryzlo K . Chong . R . Jongstra . J .
• Li Y, Guerrero A, Howard TH . The actin-binding protein, lymphocyte-specific protein 1, is expressed in human leukocytes and human myeloid and lymphoid cell lines . J. Immunol. . 155 . 7 . 3563–9 . 1995 . 10.4049/jimmunol.155.7.3563 . 7561054 .
• Misener VL . Expression of mouse LSP1/S37 isoforms. S37 is expressed in embryonic mesenchymal cells . J. Cell Sci. . 107 . 12. 3591–600 . 1995 . 7706408 . Hui C . Malapitan IA . Ittel . ME . Joyner . AL . Jongstra . J . 10.1242/jcs.107.12.3591 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Howard T . The 47-kD protein increased in neutrophil actin dysfunction with 47- and 89-kD protein abnormalities is lymphocyte-specific protein . Blood . 83 . 1 . 231–41 . 1994 . 8274738 . 10.1182/blood.V83.1.231.231. Li Y . Torres M . Guerrero . A . Coates . T . free.
• May W . Human lymphocyte-specific pp52 gene is a member of a highly conserved dispersed family . Genomics . 15 . 3 . 515–20 . 1993 . 8468046 . 10.1006/geno.1993.1102 . Korenberg JR . Chen XN . Lunsford . Lynn . Wood . William J. . Thompson . Alexic . Wall . Randolph . Denny . Christopher T. .
• Thompson AA . Alternatively spliced exons encode the tissue-specific 5' termini of leukocyte pp52 and stromal cell S37 mRNA isoforms . Genomics . 32 . 3 . 352–7 . 1997 . 8838798 . 10.1006/geno.1996.0129 . Omori SA . Gilly MJ . May . William . Gordon . Melinda S. . Wood . Jr. . Miyoshi . Erina . Malone . Cindy Sue . Gimble . Jeff .
• Huang CK, Zhan L, Ai Y, Jongstra J . LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils . J. Biol. Chem. . 272 . 1 . 17–9 . 1997 . 8995217 . 10.1074/jbc.272.1.17 . free .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . Yoshitomo-Nakagawa K . Maruyama K . Suyama . A . Sugano . S .
• Palker TJ . Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation . Hybridoma . 17 . 6 . 497–507 . 1999 . 9890705 . 10.1089/hyb.1998.17.497 . Fong AM . Scearce RM . Patel . Dhavalkumar D. . Haynes . Barton F. .
• Pulford K . Lymphocyte-specific protein 1: a specific marker of human leucocytes . Immunology . 96 . 2 . 262–71 . 1999 . 10233704 . 10.1046/j.1365-2567.1999.00677.x . 2326732 . Jones M . Banham AH . Haralambieva . Mason . E . DY .
• Zhang Q, Li Y, Howard TH . Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains . J. Immunol. . 165 . 4 . 2052–8 . 2000 . 10925289 . 10.4049/jimmunol.165.4.2052. free .
• Zhang Q, Li Y, Howard TH . Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains . Cell Motil. Cytoskeleton . 49 . 4 . 179–88 . 2002 . 11746662 . 10.1002/cm.1031 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wong MJ, Malapitan IA, Sikorski BA, Jongstra J . A cell-free binding assay maps the LSP1 cytoskeletal binding site to the COOH-terminal 30 amino acids . Biochim. Biophys. Acta . 1642 . 1–2 . 17–24 . 2003 . 12972289 . 10.1016/S0167-4889(03)00082-X .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Harrison RE, Sikorski BA, Jongstra J . Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton . J. Cell Sci. . 117 . Pt 10 . 2151–7 . 2005 . 15090600 . 10.1242/jcs.00955 . 11827355 .
• Hassel S . Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry . Proteomics . 4 . 5 . 1346–58 . 2004 . 15188402 . 10.1002/pmic.200300770 . Eichner A . Yakymovych M . Hellman . Ulf . Knaus . Petra . Souchelnytskyi . Serhiy . 6773754 .

Notes and References

1. Kadiyala RK, McIntyre BW, Krensky AM . Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen . Eur J Immunol . 20 . 11 . 2417–23 . Jan 1991 . 2174784 . 10.1002/eji.1830201109 . 35829868 .
2. Web site: Entrez Gene: LSP1 lymphocyte-specific protein 1.