| Official Name: | Lyme Center, New Hampshire |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | New Hampshire#USA |
| Pushpin Label: | Lyme Center |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | New Hampshire |
| Subdivision Type2: | County |
| Subdivision Name2: | Grafton |
| Subdivision Type3: | Town |
| Subdivision Name3: | Lyme |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 804 |
| Coordinates: | 43.7992°N -72.1253°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 03769 |
| Area Code: | 603 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 868220 |
Lyme Center is an unincorporated community in the town of Lyme in Grafton County, New Hampshire, United States. It is located close to the geographic center of the town of Lyme, approximately 2miles east of New Hampshire Route 10 where it passes through the main village of Lyme. The center of the village is listed on the National Register of Historic Places as the Lyme Center Historic District.
Lyme Center has a separate ZIP code (03769) from the rest of the town of Lyme.